TY - JOUR
T1 - Successful Intravenous Immune Globulin Therapy for Human Immunodeficiency Virus—Associated Thrombocytopenia
AU - Pollak, Andrew N.
AU - Janinis, Jim
AU - Green, David
PY - 1988/1/1
Y1 - 1988/1/1
N2 - High-dose intravenous (IV) Immune globulin was used to treat human immunodeficiency virus (HIV)—associated thrombocytopenia four times in three patients. The average platelet count at initiation of therapy was 12×109/L (12×103/mm3), and the platelet count after therapy was 159×109/L (159×103/mm3), giving a mean Increase of 147×109/L 147×103/mm3) (1225%). The conditions of two of these patients were refractory to corticosteroids, but giving IV immune globulin along with steroids appeared to enhance the response to IV immune globulin. A review of the literature revealed that 53 (88%) of 60 patients with HIV-associated thrombocytopenia responded to IV immune globulin with platelet counts greater than 50× 109/L (50×103/mm3). We conclude that IV immune globulin therapy achieves transient elevations in platelet counts to levels that control bleeding and permit surgery in patients with severe, HIV-associated thrombocytopenia.
AB - High-dose intravenous (IV) Immune globulin was used to treat human immunodeficiency virus (HIV)—associated thrombocytopenia four times in three patients. The average platelet count at initiation of therapy was 12×109/L (12×103/mm3), and the platelet count after therapy was 159×109/L (159×103/mm3), giving a mean Increase of 147×109/L 147×103/mm3) (1225%). The conditions of two of these patients were refractory to corticosteroids, but giving IV immune globulin along with steroids appeared to enhance the response to IV immune globulin. A review of the literature revealed that 53 (88%) of 60 patients with HIV-associated thrombocytopenia responded to IV immune globulin with platelet counts greater than 50× 109/L (50×103/mm3). We conclude that IV immune globulin therapy achieves transient elevations in platelet counts to levels that control bleeding and permit surgery in patients with severe, HIV-associated thrombocytopenia.
UR - http://www.scopus.com/inward/record.url?scp=0023973601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023973601&partnerID=8YFLogxK
U2 - 10.1001/archinte.1988.00380030201031
DO - 10.1001/archinte.1988.00380030201031
M3 - Article
C2 - 3277573
AN - SCOPUS:0023973601
SN - 0003-9926
VL - 148
SP - 695
EP - 697
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 3
ER -
