Successful Management of a Patient with Malignant Thyroid Teratoma

Guilherme Rabinowits; Justine Barletta; Lynette M. Sholl; Encarnacion Reche; Jochen Lorch; Laura Goguen

doi:10.1089/thy.2016.0201

Successful Management of a Patient with Malignant Thyroid Teratoma

Guilherme Rabinowits^*, Justine Barletta, Lynette M. Sholl, Encarnacion Reche, Jochen Lorch, Laura Goguen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery. Patient Findings: Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event. Summary and Conclusions: To the authors' knowledge, DICER1 mutations have not been previously reported in teratomas but have been described in PNETs, suggesting a role in the malignant transformation of this case.

Original language	English (US)
Pages (from-to)	125-128
Number of pages	4
Journal	Thyroid
Volume	27
Issue number	1
DOIs	https://doi.org/10.1089/thy.2016.0201
State	Published - Jan 2017
Externally published	Yes

Keywords

PNET
teratoma
thyroid cancer
treatment
tumor sequencing

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/thy.2016.0201

Cite this

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title = "Successful Management of a Patient with Malignant Thyroid Teratoma",

abstract = "Background: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery. Patient Findings: Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event. Summary and Conclusions: To the authors' knowledge, DICER1 mutations have not been previously reported in teratomas but have been described in PNETs, suggesting a role in the malignant transformation of this case.",

keywords = "PNET, teratoma, thyroid cancer, treatment, tumor sequencing",

author = "Guilherme Rabinowits and Justine Barletta and Sholl, {Lynette M.} and Encarnacion Reche and Jochen Lorch and Laura Goguen",

note = "Publisher Copyright: Copyright {\textcopyright} 2017, Mary Ann Liebert, Inc. 2017.",

year = "2017",

month = jan,

doi = "10.1089/thy.2016.0201",

language = "English (US)",

volume = "27",

pages = "125--128",

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publisher = "Mary Ann Liebert Inc.",

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AU - Rabinowits, Guilherme

AU - Barletta, Justine

AU - Sholl, Lynette M.

AU - Reche, Encarnacion

AU - Lorch, Jochen

AU - Goguen, Laura

PY - 2017/1

Y1 - 2017/1

N2 - Background: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery. Patient Findings: Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event. Summary and Conclusions: To the authors' knowledge, DICER1 mutations have not been previously reported in teratomas but have been described in PNETs, suggesting a role in the malignant transformation of this case.

AB - Background: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery. Patient Findings: Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event. Summary and Conclusions: To the authors' knowledge, DICER1 mutations have not been previously reported in teratomas but have been described in PNETs, suggesting a role in the malignant transformation of this case.

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KW - teratoma

KW - thyroid cancer

KW - treatment

KW - tumor sequencing

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Successful Management of a Patient with Malignant Thyroid Teratoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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