Successful management of refractory neonatal seizures with midazolam

Deepa Sirsi, Srishti Nangia, Jacqueline LaMothe*, Barry E. Kosofsky, Gail E. Solomon

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations


Seizures are indicative of underlying neurologic dysfunction in neonates. Repeated seizures may be deleterious to the brain even without disturbances of ventilation or perfusion. First-line antiepileptic drugs such as phenobarbital and phenytoin are not very effective in controlling seizures in neonates. Rapid control of status epilepticus with midazolam has been demonstrated in 2 previous studies with complete clinical and electrographic response in neonates who did not respond to phenobarbital and phenytoin. We report our experience with 3 neonates with status epilepticus. Seizures in all 3 neonates did not respond to phenobarbital and phenytoin but responded to midazolam infusion. Midazolam may be considered a safe and effective antiepileptic drug in refractory neonatal seizures of diverse etiologies.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalJournal of child neurology
Issue number6
StatePublished - Jun 1 2008


  • Midazolam
  • Neonatal seizures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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