Successful medical management of a neonate with spontaneous splenic rupture and severe hemophilia A

Sherif M Badawy*, Jenna Rossoff, Sushmita G Yallapragada, Robert I Liem, Anjali A. Sharathkumar

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Splenic rupture in neonates is a rare event, usually occurring in the setting of underlying predisposing conditions. Here, we present the case of a term neonate who presented with worsening anemia in the setting of known hemolytic disease during the newborn period and was later found to have a spontaneous splenic rupture. He was subsequently diagnosed with severe hemophilia A, and was managed medically with recombinant factor VIII replacement therapy without any surgical intervention. This is the first reported case of a neonate who had spontaneous splenic rupture and severe hemophilia A, and underwent successful medical treatment without any surgical intervention.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalHematology/ Oncology and Stem Cell Therapy
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2017

Fingerprint

Splenic Rupture
Spontaneous Rupture
Hemophilia A
Fetal Erythroblastosis
Factor VIII
Anemia
Therapeutics

Keywords

  • Factor VIII deficiency
  • Hemophilia A
  • Neonate
  • Splenic rupture

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

@article{ed66f5fb9fc34794bcdc96b128e942cc,
title = "Successful medical management of a neonate with spontaneous splenic rupture and severe hemophilia A",
abstract = "Splenic rupture in neonates is a rare event, usually occurring in the setting of underlying predisposing conditions. Here, we present the case of a term neonate who presented with worsening anemia in the setting of known hemolytic disease during the newborn period and was later found to have a spontaneous splenic rupture. He was subsequently diagnosed with severe hemophilia A, and was managed medically with recombinant factor VIII replacement therapy without any surgical intervention. This is the first reported case of a neonate who had spontaneous splenic rupture and severe hemophilia A, and underwent successful medical treatment without any surgical intervention.",
keywords = "Factor VIII deficiency, Hemophilia A, Neonate, Splenic rupture",
author = "Badawy, {Sherif M} and Jenna Rossoff and Yallapragada, {Sushmita G} and Liem, {Robert I} and Sharathkumar, {Anjali A.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.hemonc.2016.04.001",
language = "English (US)",
volume = "10",
pages = "29--32",
journal = "Hematology/ Oncology and Stem Cell Therapy",
issn = "1658-3876",
publisher = "King Faisal Specialist Hospital and Research Centre",
number = "1",

}

Successful medical management of a neonate with spontaneous splenic rupture and severe hemophilia A. / Badawy, Sherif M; Rossoff, Jenna; Yallapragada, Sushmita G; Liem, Robert I; Sharathkumar, Anjali A.

In: Hematology/ Oncology and Stem Cell Therapy, Vol. 10, No. 1, 01.03.2017, p. 29-32.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Successful medical management of a neonate with spontaneous splenic rupture and severe hemophilia A

AU - Badawy, Sherif M

AU - Rossoff, Jenna

AU - Yallapragada, Sushmita G

AU - Liem, Robert I

AU - Sharathkumar, Anjali A.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Splenic rupture in neonates is a rare event, usually occurring in the setting of underlying predisposing conditions. Here, we present the case of a term neonate who presented with worsening anemia in the setting of known hemolytic disease during the newborn period and was later found to have a spontaneous splenic rupture. He was subsequently diagnosed with severe hemophilia A, and was managed medically with recombinant factor VIII replacement therapy without any surgical intervention. This is the first reported case of a neonate who had spontaneous splenic rupture and severe hemophilia A, and underwent successful medical treatment without any surgical intervention.

AB - Splenic rupture in neonates is a rare event, usually occurring in the setting of underlying predisposing conditions. Here, we present the case of a term neonate who presented with worsening anemia in the setting of known hemolytic disease during the newborn period and was later found to have a spontaneous splenic rupture. He was subsequently diagnosed with severe hemophilia A, and was managed medically with recombinant factor VIII replacement therapy without any surgical intervention. This is the first reported case of a neonate who had spontaneous splenic rupture and severe hemophilia A, and underwent successful medical treatment without any surgical intervention.

KW - Factor VIII deficiency

KW - Hemophilia A

KW - Neonate

KW - Splenic rupture

UR - http://www.scopus.com/inward/record.url?scp=84971221585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971221585&partnerID=8YFLogxK

U2 - 10.1016/j.hemonc.2016.04.001

DO - 10.1016/j.hemonc.2016.04.001

M3 - Article

C2 - 27178624

AN - SCOPUS:84971221585

VL - 10

SP - 29

EP - 32

JO - Hematology/ Oncology and Stem Cell Therapy

JF - Hematology/ Oncology and Stem Cell Therapy

SN - 1658-3876

IS - 1

ER -