Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Carolyn M. Lorch, Nikolas W. Hayes, Jessica L. Xia, Stefan W. Fleps, Hayley E. McMorrow, Haley S. Province, Joshua A. Frydman, Jones G. Parker, Lisa R. Beutler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Rapid gut-brain communication is critical to maintain energy balance and is disrupted in diet-induced obesity. In particular, the role of carbohydrate overconsumption in the regulation of interoceptive circuits in vivo requires further investigation. Here, we report that an obesogenic high-sucrose diet (HSD) selectively blunts silencing of hunger-promoting agouti-related protein (AgRP) neurons following intragastric delivery of glucose, whereas we previously showed that overconsumption of a high-fat diet (HFD) selectively attenuates lipid-induced neural silencing. By contrast, both HSD and HFD reversibly dampen rapid AgRP neuron inhibition following chow presentation and promote intake of more palatable foods. Our findings reveal that excess sugar and fat pathologically modulate feeding circuit activity in both macronutrient-dependent and -independent ways and thus may additively exacerbate obesity.

Original languageEnglish (US)
Article number113675
JournalCell reports
Issue number2
StatePublished - Feb 27 2024


  • AgRP neurons
  • CP: Neuroscience
  • carbohydrates
  • gut-brain axis
  • metabolism
  • obesity
  • sugar-sweetened beverages

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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