Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment

Reut Parness-Yossifon*, Paul Bryar, Joanna Lynn Weinstein, Divya Srikumaran, Marilyn B Mets

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.

Original languageEnglish (US)
Pages (from-to)903-906
Number of pages4
JournalAmerican journal of ophthalmology
Volume147
Issue number5
DOIs
StatePublished - May 1 2009

Fingerprint

Retinoblastoma
Drug Therapy
Carboplatin
Etoposide
Neoplasms
Therapeutics
Eye Enucleation
Subretinal Fluid
Vincristine
Pharmaceutical Preparations
Medical Records
Seeds

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment",
abstract = "Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.",
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Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment. / Parness-Yossifon, Reut; Bryar, Paul; Weinstein, Joanna Lynn; Srikumaran, Divya; Mets, Marilyn B.

In: American journal of ophthalmology, Vol. 147, No. 5, 01.05.2009, p. 903-906.

Research output: Contribution to journalArticle

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