Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment

Reut Parness-Yossifon; Paul J. Bryar; Joanna L. Weinstein; Divya Srikumaran; Marilyn B. Mets

doi:10.1016/j.ajo.2008.12.014

Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment

Reut Parness-Yossifon^*, Paul J. Bryar, Joanna L. Weinstein, Divya Srikumaran, Marilyn B. Mets

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.

Original language	English (US)
Pages (from-to)	903-906
Number of pages	4
Journal	American journal of ophthalmology
Volume	147
Issue number	5
DOIs	https://doi.org/10.1016/j.ajo.2008.12.014
State	Published - May 2009

Funding

This study was supported by an unrestricted grant from Research to Prevent Blindness Inc, New York, New York. The authors indicate no financial conflict of interest. Involved in design of study (P.B., M.B.M.); collection of data (R.P.-Y., P.J.B., M.B.M.); analysis and interpretation of the data (P.J.B., J.L.W., M.B.M.); and preparation, review, or approval of the manuscript (R.P.-Y., P.J.B., J.L.W., D.S., M.B.M.). The Institutional Review Board of Children's Memorial Hospital's Children's Memorial Institute for Education and Research, acting as the Privacy Board, waived the need for approval of this retrospective study.

ASJC Scopus subject areas

Ophthalmology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajo.2008.12.014

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title = "Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment",

abstract = "Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.",

author = "Reut Parness-Yossifon and Bryar, {Paul J.} and Weinstein, {Joanna L.} and Divya Srikumaran and Mets, {Marilyn B.}",

note = "Funding Information: This study was supported by an unrestricted grant from Research to Prevent Blindness Inc, New York, New York. The authors indicate no financial conflict of interest. Involved in design of study (P.B., M.B.M.); collection of data (R.P.-Y., P.J.B., M.B.M.); analysis and interpretation of the data (P.J.B., J.L.W., M.B.M.); and preparation, review, or approval of the manuscript (R.P.-Y., P.J.B., J.L.W., D.S., M.B.M.). The Institutional Review Board of Children's Memorial Hospital's Children's Memorial Institute for Education and Research, acting as the Privacy Board, waived the need for approval of this retrospective study.",

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doi = "10.1016/j.ajo.2008.12.014",

language = "English (US)",

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T1 - Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment

AU - Parness-Yossifon, Reut

AU - Bryar, Paul J.

AU - Weinstein, Joanna L.

AU - Srikumaran, Divya

AU - Mets, Marilyn B.

N1 - Funding Information: This study was supported by an unrestricted grant from Research to Prevent Blindness Inc, New York, New York. The authors indicate no financial conflict of interest. Involved in design of study (P.B., M.B.M.); collection of data (R.P.-Y., P.J.B., M.B.M.); analysis and interpretation of the data (P.J.B., J.L.W., M.B.M.); and preparation, review, or approval of the manuscript (R.P.-Y., P.J.B., J.L.W., D.S., M.B.M.). The Institutional Review Board of Children's Memorial Hospital's Children's Memorial Institute for Education and Research, acting as the Privacy Board, waived the need for approval of this retrospective study.

PY - 2009/5

Y1 - 2009/5

N2 - Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.

AB - Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.

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Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment

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