TY - JOUR
T1 - Sudden Dispersion of Retinoblastoma Shortly after Initial Chemotherapy Treatment
AU - Parness-Yossifon, Reut
AU - Bryar, Paul J.
AU - Weinstein, Joanna L.
AU - Srikumaran, Divya
AU - Mets, Marilyn B.
N1 - Funding Information:
This study was supported by an unrestricted grant from Research to Prevent Blindness Inc, New York, New York. The authors indicate no financial conflict of interest. Involved in design of study (P.B., M.B.M.); collection of data (R.P.-Y., P.J.B., M.B.M.); analysis and interpretation of the data (P.J.B., J.L.W., M.B.M.); and preparation, review, or approval of the manuscript (R.P.-Y., P.J.B., J.L.W., D.S., M.B.M.). The Institutional Review Board of Children's Memorial Hospital's Children's Memorial Institute for Education and Research, acting as the Privacy Board, waived the need for approval of this retrospective study.
PY - 2009/5
Y1 - 2009/5
N2 - Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.
AB - Purpose: To present 3 cases of unilateral retinoblastoma that demonstrated unusual tumor dispersion shortly after initial chemotherapy treatment. Design: Observational case series. Methods: Review of medical records of patients in whom intraocular dissemination of retinoblastoma occurred after initial treatment with chemotherapy. Results: Three patients demonstrated an atypical response with intraocular dissemination of retinoblastoma shortly after 1 cycle of chemotherapy. All cases had unilateral retinoblastoma with no vitreous seeding or subretinal fluid at presentation. In 2 cases (Cases 2 and 3), there were a few distant subretinal seeds. Per the International Classification of Retinoblastoma, 1 tumor was group E (Case 1), and the other 2 tumors were group D1 (Cases 2 and 3). In 2 cases (Cases 1 and 2), chemotherapy included a 2-drug regimen of carboplatin and etoposide; in the third case, a 3-drug regimen of carboplatin, etoposide, and vincristine was used. In each case, the retinoblastoma dispersed with tumor cells in the vitreous shortly after initial chemotherapy treatment, leading to subsequent enucleation of the eye. Conclusions: Retinoblastoma can exhibit an unexpected and sudden dispersion of the tumor shortly after chemotherapy is initiated.
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U2 - 10.1016/j.ajo.2008.12.014
DO - 10.1016/j.ajo.2008.12.014
M3 - Article
C2 - 19232557
AN - SCOPUS:64449083658
SN - 0002-9394
VL - 147
SP - 903
EP - 906
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 5
ER -