Sudden infant death syndrome: Another year of new hope but no cure

Darius A. Loghmanee, Debra E. Weese-Mayer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


PURPOSE OF REVIEW: Sudden infant death syndrome has inspired increasingly sophisticated studies at a time when rates are declining because of the Back-to-Sleep campaign, but ethnic disparities are widening. This review evaluates and discusses original, recent research in this area. RECENT FINDINGS: The epidemiology of sudden infant death syndrome was evaluated, corroborating known risk factors and identifying new risk factors such as socioeconomic depression and air pollution. Deficits in our understanding of risk factors for this syndrome persist, suggesting a need for ethnicity-specific education, especially among the underserved. Both autopsy and genetic testing were found to improve diagnostic accuracy or identify other causes of death (e.g. long Q-T syndrome). Debate persists over counseling regarding pacifiers and co-sleeping within the context of breastfeeding. Support was found for a relationship between sudden infant death syndrome and autonomic dysregulation via the serotonergic pathway, but more research is needed. SUMMARY: The cause of sudden infant death syndrome remains elusive. Recent studies, however, suggest that improved culturally sensitive educational programs, increased diagnostic specificity, and further clarification of the link between genetics and developmental stage might further decrease the number of infants lost to this devastating disease and elucidate the mechanism(s) responsible for this syndrome.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalCurrent Opinion in Pulmonary Medicine
Issue number6
StatePublished - Nov 1 2007


  • Autonomic dysregulation
  • Long Q-T syndrome
  • Sudden infant death syndrome

ASJC Scopus subject areas

  • Medicine(all)
  • Pulmonary and Respiratory Medicine


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