Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation

Debra E Weese-Mayer; Elizabeth M. Berry-Kravis; Michael J. Ackerman; Mary L. Marazita

Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation

Debra E Weese-Mayer, Elizabeth M. Berry-Kravis, Michael J. Ackerman, Mary L. Marazita

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The 1992 “Back to Sleep” campaign identified modifiable environmental risk factors for sudden infant death syndrome (SIDS) and led to a decrease in SIDS incidence from 1.2 per 1000 live births (1) to 0.529 per 1000 live births in 2003 (2). Despite this decline, African-American infants have a 2.7-fold higher SIDS rate than Caucasian infants (2). This ethnic disparity, coupled with SIDS deaths despite improved compliance with modifiable risk factors, led investigators to consider a genetic basis for SIDS. Thus far, all genetic studies have been based on clinical, neuropathological, and epidemiological observations in SIDS victims, with subsequent identification and study of candidate genes. This chapter focuses exclusively on those genes that are pertinent to cardiorespiratory or autonomic regulation.

Original language	English (US)
Title of host publication	Sleep and Breathing in Children
Subtitle of host publication	Developmental Changes in Breathing During Sleep, Second Edition
Publisher	CRC Press
Pages	224-313
Number of pages	90
Volume	224
ISBN (Electronic)	9781420060836
ISBN (Print)	9781420060829
State	Published - Jan 1 2008

ASJC Scopus subject areas

Medicine(all)

Cite this

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abstract = "The 1992 “Back to Sleep” campaign identified modifiable environmental risk factors for sudden infant death syndrome (SIDS) and led to a decrease in SIDS incidence from 1.2 per 1000 live births (1) to 0.529 per 1000 live births in 2003 (2). Despite this decline, African-American infants have a 2.7-fold higher SIDS rate than Caucasian infants (2). This ethnic disparity, coupled with SIDS deaths despite improved compliance with modifiable risk factors, led investigators to consider a genetic basis for SIDS. Thus far, all genetic studies have been based on clinical, neuropathological, and epidemiological observations in SIDS victims, with subsequent identification and study of candidate genes. This chapter focuses exclusively on those genes that are pertinent to cardiorespiratory or autonomic regulation.",

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Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation. / Weese-Mayer, Debra E; Berry-Kravis, Elizabeth M.; Ackerman, Michael J. et al.
Sleep and Breathing in Children: Developmental Changes in Breathing During Sleep, Second Edition. Vol. 224 CRC Press, 2008. p. 224-313.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation

Abstract

ASJC Scopus subject areas

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