Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance)

Michael A. Fuchs, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al B Benson III, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Shuji Ogino, Kana Wu, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. Methods: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. Results: Patients consuming ≥2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming <2 servings per month (Ptrend = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥25 kg/m 2) and less physically active (metabolic equivalent task-hours per week < 18) (HR = 2.22; 95% CI, 1.29-3.81, Ptrend = 0.0025). Conclusion: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.

Original languageEnglish (US)
Article numbere99816
JournalPloS one
Volume9
Issue number6
DOIs
StatePublished - Jun 17 2014

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Beverages
Sugars
beverages
colorectal neoplasms
Colonic Neoplasms
sugars
Hazards
Recurrence
neoplasms
Survival
confidence interval
Mortality
Confidence Intervals
Neoplasms
obesity
Obesity
Metabolic Equivalent
Sedentary Lifestyle
Chemotherapy
National Cancer Institute (U.S.)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Fuchs, M. A., Sato, K., Niedzwiecki, D., Ye, X., Saltz, L. B., Mayer, R. J., ... Meyerhardt, J. A. (2014). Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance). PloS one, 9(6), [e99816]. https://doi.org/10.1371/journal.pone.0099816
Fuchs, Michael A. ; Sato, Kaori ; Niedzwiecki, Donna ; Ye, Xing ; Saltz, Leonard B. ; Mayer, Robert J. ; Mowat, Rex B. ; Whittom, Renaud ; Hantel, Alexander ; Benson III, Al B ; Atienza, Daniel ; Messino, Michael ; Kindler, Hedy ; Venook, Alan ; Ogino, Shuji ; Wu, Kana ; Willett, Walter C. ; Giovannucci, Edward L. ; Meyerhardt, Jeffrey A. / Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance). In: PloS one. 2014 ; Vol. 9, No. 6.
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title = "Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance)",
abstract = "Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. Methods: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95{\%} confidence intervals (CIs) were calculated with Cox proportional hazard models. Results: Patients consuming ≥2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95{\%} CI, 1.04-2.68), compared with those consuming <2 servings per month (Ptrend = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥25 kg/m 2) and less physically active (metabolic equivalent task-hours per week < 18) (HR = 2.22; 95{\%} CI, 1.29-3.81, Ptrend = 0.0025). Conclusion: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.",
author = "Fuchs, {Michael A.} and Kaori Sato and Donna Niedzwiecki and Xing Ye and Saltz, {Leonard B.} and Mayer, {Robert J.} and Mowat, {Rex B.} and Renaud Whittom and Alexander Hantel and {Benson III}, {Al B} and Daniel Atienza and Michael Messino and Hedy Kindler and Alan Venook and Shuji Ogino and Kana Wu and Willett, {Walter C.} and Giovannucci, {Edward L.} and Meyerhardt, {Jeffrey A.}",
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Fuchs, MA, Sato, K, Niedzwiecki, D, Ye, X, Saltz, LB, Mayer, RJ, Mowat, RB, Whittom, R, Hantel, A, Benson III, AB, Atienza, D, Messino, M, Kindler, H, Venook, A, Ogino, S, Wu, K, Willett, WC, Giovannucci, EL & Meyerhardt, JA 2014, 'Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance)', PloS one, vol. 9, no. 6, e99816. https://doi.org/10.1371/journal.pone.0099816

Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance). / Fuchs, Michael A.; Sato, Kaori; Niedzwiecki, Donna; Ye, Xing; Saltz, Leonard B.; Mayer, Robert J.; Mowat, Rex B.; Whittom, Renaud; Hantel, Alexander; Benson III, Al B; Atienza, Daniel; Messino, Michael; Kindler, Hedy; Venook, Alan; Ogino, Shuji; Wu, Kana; Willett, Walter C.; Giovannucci, Edward L.; Meyerhardt, Jeffrey A.

In: PloS one, Vol. 9, No. 6, e99816, 17.06.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance)

AU - Fuchs, Michael A.

AU - Sato, Kaori

AU - Niedzwiecki, Donna

AU - Ye, Xing

AU - Saltz, Leonard B.

AU - Mayer, Robert J.

AU - Mowat, Rex B.

AU - Whittom, Renaud

AU - Hantel, Alexander

AU - Benson III, Al B

AU - Atienza, Daniel

AU - Messino, Michael

AU - Kindler, Hedy

AU - Venook, Alan

AU - Ogino, Shuji

AU - Wu, Kana

AU - Willett, Walter C.

AU - Giovannucci, Edward L.

AU - Meyerhardt, Jeffrey A.

PY - 2014/6/17

Y1 - 2014/6/17

N2 - Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. Methods: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. Results: Patients consuming ≥2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming <2 servings per month (Ptrend = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥25 kg/m 2) and less physically active (metabolic equivalent task-hours per week < 18) (HR = 2.22; 95% CI, 1.29-3.81, Ptrend = 0.0025). Conclusion: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.

AB - Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. Methods: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. Results: Patients consuming ≥2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming <2 servings per month (Ptrend = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥25 kg/m 2) and less physically active (metabolic equivalent task-hours per week < 18) (HR = 2.22; 95% CI, 1.29-3.81, Ptrend = 0.0025). Conclusion: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.

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U2 - 10.1371/journal.pone.0099816

DO - 10.1371/journal.pone.0099816

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VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

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