SUMO Weighs In on a Photoreceptor Finish

Carole LaBonne*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.

Original languageEnglish (US)
Pages (from-to)165-166
Number of pages2
JournalDevelopmental Cell
Volume16
Issue number2
DOIs
StatePublished - Feb 17 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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