Identifikation maligner Pleura-Ergüsse mittels 18F-Fluordeoxyglukose-PET/CT - Eine Korrelation mit zytopathologischen Befunden

Translated title of the contribution: 18F-fluorodeoxyglucose PET/CT findings in pleural effusions of patients with known cancer

I. Letovanec, G. Allenbach, A. Mihaescu, M. Nicod Lalonde, S. Schmidt, R. Stupp, J. W. Fitting, A. Boubaker, H. B. Ris, John O. Prior

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Aim: Pleural effusion is common in cancer patients and to determine its malignant origin is of huge clinical significance. PET/CT with 18F-FDG is of diagnostic value in staging and follow-up, but its ability to differentiate between malignant and benign effusions is not precisely known. Patients, methods: We examined 50 PET/CT from 47 patients (29 men, 18 women, 60 ± 16 years) with pleural effusion and known cancer (24 NSCLC, 7 lymphomas, 5 breasts, 4 GIST, 3 mesotheliomas, 2 head and neck, 2 malignant teratoma, 1 colorectal, 1 oesophageal, 1 melanoma) for FDG uptake in the effusions using SUV max. This was correlated to cytopathology performed after a median of 21 days (interquartile range -3 to 23), which included pH, relative distribution (macrophages, neutrophils, eosinophils, basophils, lymphocytes, plasmocytes), and absolute cell count. Results: Malignant cells were found in 17 effusions (34%) (6 NSCLC, 5 lymphomas, 2 breasts, 2 mesotheliomas, 2 malignant teratomas). SUV in malignant effusions were higher than in benign ones [3.7 (95%CI 1.8-5.6) vs. 1.7 g/ml (1.5-1.9), p = 0.001], with a correlation between malignant effuUntersion and SUV (Spearman coefficient ρ = 0.50, p = 0.001), but not with other cytopathological or radiological parameters (ROC area 0.83 ± 0.06). Using a 2.2-mg/l SUV threshold, 12 PET/CT studies were positive and 38 negative with sensitivity, specificity, positive and negative predictive values of 53%, 91%, 75% and 79%, respectively. For NSCLC only (n = 24), ROC area was 0.95 ± 0.04, 7 studies were positive and 17 negative with a sensitivity, specificity, positive and negative predictive values of 83%, 89%, 71 and 94%, respectively. Conclusion: PET/CT may help to differentiate the malignant or benign origin of a pleural effusion with a high specificity in patients with known cancer, in particular NSCLC.

Translated title of the contribution18F-fluorodeoxyglucose PET/CT findings in pleural effusions of patients with known cancer
Original languageGerman
Pages (from-to)186-193
Number of pages8
JournalNuklearMedizin
Volume51
Issue number5
DOIs
StatePublished - Oct 16 2012

Keywords

  • FDG
  • PET/CT
  • Pleural effusion
  • Tumour

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of '<sup>18</sup>F-fluorodeoxyglucose PET/CT findings in pleural effusions of patients with known cancer'. Together they form a unique fingerprint.

Cite this