TY - JOUR
T1 - 18F-NaF PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE
AU - Papadakis, Georgios Z.
AU - Manikis, Georgios C.
AU - Karantanas, Apostolos H.
AU - Florenzano, Pablo
AU - Bagci, Ulas
AU - Marias, Kostas
AU - Collins, Michael T.
AU - Boyce, Alison M.
N1 - Funding Information:
This study was funded by the Intramural Research Program of the National Institute of Dental and Craniofacial Research, National Institutes of Health. Authors' roles: Study design: GZP, MTC, and AMB. Study conduct: GZP, MTC, and AMB. Data collection: GZP and AMB. Data analysis: GZP, GCM, and AMB. Data interpretation: GZP, GCM, PF, AHK, UB, KM, and AMB. Drafting manuscript: GZP, GCM, and AMB. Revising manuscript content: GZP, GCM, and AMB. Approving final version of manuscript: GZP, GCM, PF, AHK, UB, KM, MTC, and AMB. AMB takes responsibility for the integrity of the data analysis.
Publisher Copyright:
© 2019 American Society for Bone and Mineral Research
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity. The purpose of this study was to investigate the utility of 18F-NaF PET/CT imaging in quantifying disease activity in patients with FD. Fifteen consecutively evaluated subjects underwent whole-body 18F-NaF PET/CT scans, and FD burden was assessed by quantifying FD-related 18F-NaF activity. 18F-NaF PET/CT parameters obtained included (i) SUVmax (standardized uptake value [SUV] of the FD lesion with the highest uptake); (ii) SUVmean (average SUV of all 18F-NaF–positive FD lesions); (iii) total volume of all 18F-NaF–positive FD lesions (TV); and (iv) total FD lesion activity determined as the product of TV multiplied by SUVmean (TA = TV × SUVmean) (TA). Skeletal outcomes, functional outcomes, and bone turnover markers were correlated with 18F-NaF PET/CT parameters. TV and TA of extracranial FD lesions correlated strongly with skeletal outcomes including fractures and surgeries (p values ≤ 0.003). Subjects with impaired ambulation and scoliosis had significantly higher TV and TA values (P < 0.05), obtained from extracranial and spinal lesions, respectively. Craniofacial surgeries correlated with TV and TA of skull FD lesions (P < 0.001). Bone turnover markers, including alkaline phosphatase, N-telopeptides, and osteocalcin, were strongly correlated with TV and TA (P < 0.05) extracted from FD lesions in the entire skeleton. No associations were identified with SUVmax or SUVmean. Bone pain and age did not correlate with 18F-NaF PET/CT parameters. FD burden evaluated by 18F-NaF-PET/CT facilitates accurate assessment of FD activity, and correlates quantitatively with clinically-relevant skeletal outcomes.
AB - Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity. The purpose of this study was to investigate the utility of 18F-NaF PET/CT imaging in quantifying disease activity in patients with FD. Fifteen consecutively evaluated subjects underwent whole-body 18F-NaF PET/CT scans, and FD burden was assessed by quantifying FD-related 18F-NaF activity. 18F-NaF PET/CT parameters obtained included (i) SUVmax (standardized uptake value [SUV] of the FD lesion with the highest uptake); (ii) SUVmean (average SUV of all 18F-NaF–positive FD lesions); (iii) total volume of all 18F-NaF–positive FD lesions (TV); and (iv) total FD lesion activity determined as the product of TV multiplied by SUVmean (TA = TV × SUVmean) (TA). Skeletal outcomes, functional outcomes, and bone turnover markers were correlated with 18F-NaF PET/CT parameters. TV and TA of extracranial FD lesions correlated strongly with skeletal outcomes including fractures and surgeries (p values ≤ 0.003). Subjects with impaired ambulation and scoliosis had significantly higher TV and TA values (P < 0.05), obtained from extracranial and spinal lesions, respectively. Craniofacial surgeries correlated with TV and TA of skull FD lesions (P < 0.001). Bone turnover markers, including alkaline phosphatase, N-telopeptides, and osteocalcin, were strongly correlated with TV and TA (P < 0.05) extracted from FD lesions in the entire skeleton. No associations were identified with SUVmax or SUVmean. Bone pain and age did not correlate with 18F-NaF PET/CT parameters. FD burden evaluated by 18F-NaF-PET/CT facilitates accurate assessment of FD activity, and correlates quantitatively with clinically-relevant skeletal outcomes.
KW - ANALYSIS/QUANTITATION OF BONE (OTHER)
KW - BIOCHEMICAL MARKERS OF BONE TURNOVER
KW - DISEASES AND DISORDERS OF/RELATED TO BONE (OTHER)
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U2 - 10.1002/jbmr.3738
DO - 10.1002/jbmr.3738
M3 - Article
C2 - 31116487
AN - SCOPUS:85066916213
SN - 0884-0431
VL - 34
SP - 1619
EP - 1631
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 9
ER -