18F-NaF PET/CT in extensive melorheostosis of the axial and appendicular skeleton with soft-tissue involvement

Georgios Z. Papadakis; Smita Jha; Timothy Bhattacharyya; Corina Millo; Tsang Wei Tu; Ulas Bagci; Kostas Marias; Apostolos H. Karantanas; Nicholas J. Patronas

doi:10.1097/RLU.0000000000001647

¹⁸F-NaF PET/CT in extensive melorheostosis of the axial and appendicular skeleton with soft-tissue involvement

Georgios Z. Papadakis^*, Smita Jha, Timothy Bhattacharyya, Corina Millo, Tsang Wei Tu, Ulas Bagci, Kostas Marias, Apostolos H. Karantanas, Nicholas J. Patronas

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body ¹⁸F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased ¹⁸F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity.

Original language	English (US)
Pages (from-to)	537-539
Number of pages	3
Journal	Clinical nuclear medicine
Volume	42
Issue number	7
DOIs	https://doi.org/10.1097/RLU.0000000000001647
State	Published - Mar 17 2017
Externally published	Yes

Keywords

Bone dysplasia
F-NaF PET/CT
Melorheostosis
Osteosclerosis
Soft-tissue ossified masses

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000001647

Cite this

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title = "18F-NaF PET/CT in extensive melorheostosis of the axial and appendicular skeleton with soft-tissue involvement",

abstract = "Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body 18F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased 18F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity.",

keywords = "Bone dysplasia, F-NaF PET/CT, Melorheostosis, Osteosclerosis, Soft-tissue ossified masses",

author = "Papadakis, {Georgios Z.} and Smita Jha and Timothy Bhattacharyya and Corina Millo and Tu, {Tsang Wei} and Ulas Bagci and Kostas Marias and Karantanas, {Apostolos H.} and Patronas, {Nicholas J.}",

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T1 - 18F-NaF PET/CT in extensive melorheostosis of the axial and appendicular skeleton with soft-tissue involvement

AU - Papadakis, Georgios Z.

AU - Jha, Smita

AU - Bhattacharyya, Timothy

AU - Millo, Corina

AU - Tu, Tsang Wei

AU - Bagci, Ulas

AU - Marias, Kostas

AU - Karantanas, Apostolos H.

AU - Patronas, Nicholas J.

PY - 2017/3/17

Y1 - 2017/3/17

N2 - Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body 18F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased 18F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity.

AB - Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body 18F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased 18F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity.

KW - Bone dysplasia

KW - F-NaF PET/CT

KW - Melorheostosis

KW - Osteosclerosis

KW - Soft-tissue ossified masses

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