3H-imipramine binding in blood platelets of schizophrenic patients

Ramesh C. Arora, Joseph J. Locascio, Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

3H-Imipramine binding was studied in the blood platelets of 51 unmedicated chronic schizophrenic patients. Univariate analyses of log-transformed data revealed that Bmax was significantly lower in shcizophrenic patients than normal volunteers; Kd was nonsignificantly higher in the schizophrenics. A multivariate analysis of variance indicated the Kd and Bmax both differ significantly between normal controls and shcizophrenic patients in the direction of increased Kd and decreased Bmax in the schizophrenics. These results indicate that decreased platelet imipramine binding is not specific for major depression.

Original languageEnglish (US)
Pages (from-to)215-224
Number of pages10
JournalPsychiatry Research
Volume19
Issue number3
DOIs
StatePublished - Nov 1986

Keywords

  • H-Imipramine binding
  • K and B
  • blood platelets
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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