3H-imipramine binding in blood platelets of schizophrenic patients

Ramesh C. Arora; Joseph J. Locascio; Herbert Y. Meltzer

doi:10.1016/0165-1781(86)90100-9

³H-imipramine binding in blood platelets of schizophrenic patients

Ramesh C. Arora, Joseph J. Locascio, Herbert Y. Meltzer^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

³H-Imipramine binding was studied in the blood platelets of 51 unmedicated chronic schizophrenic patients. Univariate analyses of log-transformed data revealed that B_max was significantly lower in shcizophrenic patients than normal volunteers; K_d was nonsignificantly higher in the schizophrenics. A multivariate analysis of variance indicated the K_d and B_max both differ significantly between normal controls and shcizophrenic patients in the direction of increased K_d and decreased B_max in the schizophrenics. These results indicate that decreased platelet imipramine binding is not specific for major depression.

Original language	English (US)
Pages (from-to)	215-224
Number of pages	10
Journal	Psychiatry Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(86)90100-9
State	Published - Nov 1986

Funding

Acknowledgments. The research reported was supported, in part, by USPHS MH-30059, MH-41684, MH-41594, and the Cleveland Foundation. H.Y.M. is recipient of USPHS Research Career Scientist Award MH-47808.

Keywords

H-Imipramine binding
K and B
blood platelets
schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-1781(86)90100-9

Cite this

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title = "3H-imipramine binding in blood platelets of schizophrenic patients",

abstract = "3H-Imipramine binding was studied in the blood platelets of 51 unmedicated chronic schizophrenic patients. Univariate analyses of log-transformed data revealed that Bmax was significantly lower in shcizophrenic patients than normal volunteers; Kd was nonsignificantly higher in the schizophrenics. A multivariate analysis of variance indicated the Kd and Bmax both differ significantly between normal controls and shcizophrenic patients in the direction of increased Kd and decreased Bmax in the schizophrenics. These results indicate that decreased platelet imipramine binding is not specific for major depression.",

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author = "Arora, {Ramesh C.} and Locascio, {Joseph J.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Acknowledgments. The research reported was supported, in part, by USPHS MH-30059, MH-41684, MH-41594, and the Cleveland Foundation. H.Y.M. is recipient of USPHS Research Career Scientist Award MH-47808.",

year = "1986",

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AU - Locascio, Joseph J.

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N2 - 3H-Imipramine binding was studied in the blood platelets of 51 unmedicated chronic schizophrenic patients. Univariate analyses of log-transformed data revealed that Bmax was significantly lower in shcizophrenic patients than normal volunteers; Kd was nonsignificantly higher in the schizophrenics. A multivariate analysis of variance indicated the Kd and Bmax both differ significantly between normal controls and shcizophrenic patients in the direction of increased Kd and decreased Bmax in the schizophrenics. These results indicate that decreased platelet imipramine binding is not specific for major depression.

AB - 3H-Imipramine binding was studied in the blood platelets of 51 unmedicated chronic schizophrenic patients. Univariate analyses of log-transformed data revealed that Bmax was significantly lower in shcizophrenic patients than normal volunteers; Kd was nonsignificantly higher in the schizophrenics. A multivariate analysis of variance indicated the Kd and Bmax both differ significantly between normal controls and shcizophrenic patients in the direction of increased Kd and decreased Bmax in the schizophrenics. These results indicate that decreased platelet imipramine binding is not specific for major depression.

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