3H-imipramine binding in the frontal cortex of suicides

Ramesh C. Arora*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Imipramine binding (desipramine- and serotonin-sensitive) was determined in the frontal cortex of suicide victims and nonpsychiatric controls who died due to medical disease or accidents. There were no differences in Kd or Bmax of imipramine binding between controls and suicides. The Kd and Bmax values of serotonin-sensitive imipramine binding were significantly lower than desipramine-sensitive imipramine binding, both in controls and suicides. There were significant correlations between Kd and Bmax of serotonin-sensitive imipramine binding and desipramine-sensitive imipramine binding in suicides but not in controls.

Original languageEnglish (US)
Pages (from-to)125-135
Number of pages11
JournalPsychiatry Research
Volume30
Issue number2
DOIs
StatePublished - Nov 1989

Keywords

  • Imipramine binding
  • brain
  • desipramine
  • serotonin
  • suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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