³H-imipramine binding in the frontal cortex of suicides

Imipramine binding (desipramine- and serotonin-sensitive) was determined in the frontal cortex of suicide victims and nonpsychiatric controls who died due to medical disease or accidents. There were no differences in K_d or B_max of imipramine binding between controls and suicides. The K_d and B_max values of serotonin-sensitive imipramine binding were significantly lower than desipramine-sensitive imipramine binding, both in controls and suicides. There were significant correlations between K_d and B_max of serotonin-sensitive imipramine binding and desipramine-sensitive imipramine binding in suicides but not in controls.