90Y radiation lobectomy: Outcomes following surgical resection in patients with hepatic tumors and small future liver remnant volumes

Robert J. Lewandowski*, Larry Donahue, Attasit Chokechanachaisakul, Laura Kulik, Samdeep Mouli, Juan Caicedo, Michael Abecassis, Jonathan Fryer, Riad Salem, Talia Baker

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Background: The purpose of this study is to assess operative, post-operative, and long-term outcomes in patients who underwent radiation lobectomy (RL) for tumor control and/or hypertrophy of small future liver remnant (FLR) prior to resection. Methods: Right lobar +/− segment 4 radioembolization was performed prior to lobectomy/tri-segmentectomy in patients with hepatic tumor but inadequate FLR. Parenchymal/tumor volumes were calculated from pre/post-RL imaging; FLR/%FLR hypertrophy were determined. Complications were graded by the Clavien-Dindo classification. Results: Thirteen patients (HCC n = 10, cholangiocarcinoma n = 2, mCRC n = 1) underwent RL prior to resection. The median time between RL and post-RL imaging was 40 days (23–190 days); the median time to resection was 86 days (30–210 days). Median FLR increased significantly [pre: 33% (22–43%); post: 43% (29–69%), P < 0.01] to yield a median %FLR hypertrophy of 30% (4–105%). The median hospital stay after resection was 4 days (3–11 days). Transient hepatobiliary toxicities normalized post-operatively. Ninety-two percent of resected tumors had >50% pathologic necrosis. Median follow up time after surgery was 604 days (144–1,416 days); one death occurred. Conclusions: In this preliminary study, radiation lobectomy was a safe and effective method to achieve remnant liver hypertrophy while providing tumor control. This approach may facilitate safe resection and favorable post-operative outcomes.J. Surg. Oncol. 2016;114:99–105.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalJournal of Surgical Oncology
Volume114
Issue number1
DOIs
StatePublished - Jul 1 2016

Keywords

  • future liver remnant
  • hepatectomy
  • radioembolization
  • resection
  • yttrium-90

ASJC Scopus subject areas

  • Surgery
  • Oncology

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