Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Sung Bong Kim, Yi Zhang, Sang Min Won, Amay J. Bandodkar, Yurina Sekine, Yeguang Xue, Jahyun Koo, Sean W. Harshman, Jennifer A. Martin, Jeong Min Park, Tyler R. Ray, Kaitlyn E. Crawford, Kyu Tae Lee, Jungil Choi, Rhonda L. Pitsch, Claude C. Grigsby, Adam J. Strang, Yu Yu Chen, Shuai Xu, Jeonghyun Kim & 5 others Ahyeon Koh, Jeong Sook Ha, Yonggang Huang, Seung Wook Kim*, John A Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

Original languageEnglish (US)
Article number1703334
JournalSmall
Volume14
Issue number12
DOIs
StatePublished - Mar 22 2018

Fingerprint

Microfluidics
Sweat
Lab-On-A-Chip Devices
Chlorides
Skin
Polymers
Eccrine Glands
Sampling
Color
Technology

Keywords

  • microfluidics
  • perspiration
  • super absorbent polymer
  • sweat chloride

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)

Cite this

Kim, Sung Bong ; Zhang, Yi ; Won, Sang Min ; Bandodkar, Amay J. ; Sekine, Yurina ; Xue, Yeguang ; Koo, Jahyun ; Harshman, Sean W. ; Martin, Jennifer A. ; Park, Jeong Min ; Ray, Tyler R. ; Crawford, Kaitlyn E. ; Lee, Kyu Tae ; Choi, Jungil ; Pitsch, Rhonda L. ; Grigsby, Claude C. ; Strang, Adam J. ; Chen, Yu Yu ; Xu, Shuai ; Kim, Jeonghyun ; Koh, Ahyeon ; Ha, Jeong Sook ; Huang, Yonggang ; Kim, Seung Wook ; Rogers, John A. / Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. In: Small. 2018 ; Vol. 14, No. 12.
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title = "Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics",
abstract = "This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.",
keywords = "microfluidics, perspiration, super absorbent polymer, sweat chloride",
author = "Kim, {Sung Bong} and Yi Zhang and Won, {Sang Min} and Bandodkar, {Amay J.} and Yurina Sekine and Yeguang Xue and Jahyun Koo and Harshman, {Sean W.} and Martin, {Jennifer A.} and Park, {Jeong Min} and Ray, {Tyler R.} and Crawford, {Kaitlyn E.} and Lee, {Kyu Tae} and Jungil Choi and Pitsch, {Rhonda L.} and Grigsby, {Claude C.} and Strang, {Adam J.} and Chen, {Yu Yu} and Shuai Xu and Jeonghyun Kim and Ahyeon Koh and Ha, {Jeong Sook} and Yonggang Huang and Kim, {Seung Wook} and Rogers, {John A}",
year = "2018",
month = "3",
day = "22",
doi = "10.1002/smll.201703334",
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Kim, SB, Zhang, Y, Won, SM, Bandodkar, AJ, Sekine, Y, Xue, Y, Koo, J, Harshman, SW, Martin, JA, Park, JM, Ray, TR, Crawford, KE, Lee, KT, Choi, J, Pitsch, RL, Grigsby, CC, Strang, AJ, Chen, YY, Xu, S, Kim, J, Koh, A, Ha, JS, Huang, Y, Kim, SW & Rogers, JA 2018, 'Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics', Small, vol. 14, no. 12, 1703334. https://doi.org/10.1002/smll.201703334

Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. / Kim, Sung Bong; Zhang, Yi; Won, Sang Min; Bandodkar, Amay J.; Sekine, Yurina; Xue, Yeguang; Koo, Jahyun; Harshman, Sean W.; Martin, Jennifer A.; Park, Jeong Min; Ray, Tyler R.; Crawford, Kaitlyn E.; Lee, Kyu Tae; Choi, Jungil; Pitsch, Rhonda L.; Grigsby, Claude C.; Strang, Adam J.; Chen, Yu Yu; Xu, Shuai; Kim, Jeonghyun; Koh, Ahyeon; Ha, Jeong Sook; Huang, Yonggang; Kim, Seung Wook; Rogers, John A.

In: Small, Vol. 14, No. 12, 1703334, 22.03.2018.

Research output: Contribution to journalArticle

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T1 - Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

AU - Kim, Sung Bong

AU - Zhang, Yi

AU - Won, Sang Min

AU - Bandodkar, Amay J.

AU - Sekine, Yurina

AU - Xue, Yeguang

AU - Koo, Jahyun

AU - Harshman, Sean W.

AU - Martin, Jennifer A.

AU - Park, Jeong Min

AU - Ray, Tyler R.

AU - Crawford, Kaitlyn E.

AU - Lee, Kyu Tae

AU - Choi, Jungil

AU - Pitsch, Rhonda L.

AU - Grigsby, Claude C.

AU - Strang, Adam J.

AU - Chen, Yu Yu

AU - Xu, Shuai

AU - Kim, Jeonghyun

AU - Koh, Ahyeon

AU - Ha, Jeong Sook

AU - Huang, Yonggang

AU - Kim, Seung Wook

AU - Rogers, John A

PY - 2018/3/22

Y1 - 2018/3/22

N2 - This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

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KW - microfluidics

KW - perspiration

KW - super absorbent polymer

KW - sweat chloride

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