Superstructured Biomaterials Formed by Exchange Dynamics and Host–Guest Interactions in Supramolecular Polymers

Alexandra N. Edelbrock, Tristan D. Clemons, Stacey M. Chin, Joshua J.W. Roan, Eric P. Bruckner, Zaida Álvarez, Jack F. Edelbrock, Kristen S. Wek, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Dynamic and reversible assembly of molecules is ubiquitous in the hierarchical superstructures of living systems and plays a key role in cellular functions. Recent work from the laboratory reported on the reversible formation of such superstructures in systems of peptide amphiphiles conjugated to oligonucleotides and electrostatically complimentary peptide sequences. Here, a supramolecular system is reported upon where exchange dynamics and host–guest interactions between β-cyclodextrin and adamantane on peptide amphiphiles lead to superstructure formation. Superstructure formation with bundled nanoribbons generates a mechanically robust hydrogel with a highly porous architecture that can be 3D printed. Functionalization of the porous superstructured material with a biological signal results in a matrix with significant in vitro bioactivity toward neurons that could be used as a supramolecular model to design novel biomaterials.

Original languageEnglish (US)
Article number2004042
JournalAdvanced Science
Issue number8
StatePublished - Apr 21 2021


  • 3D printing
  • adamantane
  • biomaterials
  • cyclodextrin
  • host–guest
  • peptide amphiphile
  • superstructure

ASJC Scopus subject areas

  • General Engineering
  • General Physics and Astronomy
  • General Chemical Engineering
  • General Materials Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Medicine (miscellaneous)


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