Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

Bin Liu; Dan Yi; Jiakai Pan; Jingbo Dai; Maggie M. Zhu; You Yang Zhao; S. Paul Oh; Michael B. Fallon; Zhiyu Dai

doi:10.1002/pul2.12056

Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

Bin Liu, Dan Yi, Jiakai Pan, Jingbo Dai, Maggie M. Zhu, You Yang Zhao, S. Paul Oh, Michael B. Fallon, Zhiyu Dai^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

Original language	English (US)
Article number	e12056
Journal	Pulmonary Circulation
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/pul2.12056
State	Published - Jan 2022

Funding

This study was supported in part by NIH grants R01HL140409, R01HL133951, R01HL148810 to You‐Yang Zhao, and NIH R00HL13827, AHA Career Development Award 20CDA35310084, ATS Foundation Pulmonary Hypertension Association Research Fellowship, Arizona Biomedical Research Centre funding (ADHS18‐198871), and the University of Arizona departmental Startup funding to Zhiyu Dai. The authors thank the Pulmonary Hypertension Breakthrough Initiative for providing the lung endothelial cells from IPAH patients and failed donors. Funding for the Pulmonary Hypertension Breakthrough Initiative is provided under an NHLBI R24 grant (R24HL123767).

Keywords

BMPR2
angiogenesis
hypoxia
pulmonary hypertension

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pul2.12056

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title = "Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension",

abstract = "BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.",

keywords = "BMPR2, angiogenesis, hypoxia, pulmonary hypertension",

author = "Bin Liu and Dan Yi and Jiakai Pan and Jingbo Dai and Zhu, {Maggie M.} and Zhao, {You Yang} and Oh, {S. Paul} and Fallon, {Michael B.} and Zhiyu Dai",

note = "Funding Information: This study was supported in part by NIH grants R01HL140409, R01HL133951, R01HL148810 to You‐Yang Zhao, and NIH R00HL13827, AHA Career Development Award 20CDA35310084, ATS Foundation Pulmonary Hypertension Association Research Fellowship, Arizona Biomedical Research Centre funding (ADHS18‐198871), and the University of Arizona departmental Startup funding to Zhiyu Dai. The authors thank the Pulmonary Hypertension Breakthrough Initiative for providing the lung endothelial cells from IPAH patients and failed donors. Funding for the Pulmonary Hypertension Breakthrough Initiative is provided under an NHLBI R24 grant (R24HL123767). Publisher Copyright: {\textcopyright} 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.",

year = "2022",

month = jan,

doi = "10.1002/pul2.12056",

language = "English (US)",

volume = "12",

journal = "Pulmonary Circulation",

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T1 - Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

AU - Liu, Bin

AU - Yi, Dan

AU - Pan, Jiakai

AU - Dai, Jingbo

AU - Zhu, Maggie M.

AU - Zhao, You Yang

AU - Oh, S. Paul

AU - Fallon, Michael B.

AU - Dai, Zhiyu

N1 - Funding Information: This study was supported in part by NIH grants R01HL140409, R01HL133951, R01HL148810 to You‐Yang Zhao, and NIH R00HL13827, AHA Career Development Award 20CDA35310084, ATS Foundation Pulmonary Hypertension Association Research Fellowship, Arizona Biomedical Research Centre funding (ADHS18‐198871), and the University of Arizona departmental Startup funding to Zhiyu Dai. The authors thank the Pulmonary Hypertension Breakthrough Initiative for providing the lung endothelial cells from IPAH patients and failed donors. Funding for the Pulmonary Hypertension Breakthrough Initiative is provided under an NHLBI R24 grant (R24HL123767). Publisher Copyright: © 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.

PY - 2022/1

Y1 - 2022/1

N2 - BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

AB - BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

KW - BMPR2

KW - angiogenesis

KW - hypoxia

KW - pulmonary hypertension

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ER -

Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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