Suppression of interstitial nephritis by auto-anti-idiotypic immunity

E. G. Neilson, S. M. Phillips

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.

Original languageEnglish (US)
Pages (from-to)179-189
Number of pages11
JournalJournal of Experimental Medicine
Volume155
Issue number1
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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