Suppression of sympathetic nervous system during fasting

James B. Young*, Lewis Landsberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

302 Scopus citations

Abstract

Two days of fasting in rats significantly reduces the turnover of norepinephrine in the heart. In contrast to the effects of ganglionic blockade in fed controls, similar blockade in fasted animals is without significant effect on [3H]-norepinephrine retention or endogenous norepinephrine in the heart. These data are consistent with suppression of centrally mediated sympathetic activity in the fasted state. The decrease in norepinephrine turnover during fasting is completely reversed by 1 day of refeeding.

Original languageEnglish (US)
Pages (from-to)1473-1475
Number of pages3
JournalScience
Volume196
Issue number4297
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • General

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