Suppressive factor or factors derived from head and neck squamous cell carcinoma induce apoptosis in activated lymphocytes

Kathleen R Billings, M. B. Wang*, A. K. Lichtenstein

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Our laboratory has previously identified a soluble factor derived from head and neck squamous cell carcinoma that impairs lymphocyte proliferative responses in vitro. This study further investigates the nature of the interaction between these factors and T lymphocytes. The proliferative activity of phytohemagglutinin-stimulated peripheral blood lymphocytes and the Jurkat T-cell line was significantly suppressed (>50%) by the supernatants of 13 (41.9%) of 31 recently explanted head and neck squamous cell carcinoma samples. A characteristic morphologic appearance of these suppressed cells and ladderlike pattern of DNA fragmentation on gel electrophoresis indicated that the suppressive supernatants were inducing or predisposing T cells to apoptotic death. This apoptosis-inducing activity may be similar to that previously described in a suppressive supernatant obtained from an esophageal carcinoma cell line. These results shed further light on the mechanism behind a soluble immunosuppressive factor or factors produced by head and neck squamous cell carcinoma.

Original languageEnglish (US)
Pages (from-to)458-465
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Volume116
Issue number4
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Suppressive factor or factors derived from head and neck squamous cell carcinoma induce apoptosis in activated lymphocytes'. Together they form a unique fingerprint.

  • Cite this