Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants*

Henry N. Claman, Stephen D. Miller, Man Sun Sy

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Genetic restrictions in generation and expression of hapten-specific suppressor cells for contact sensitivity were found. Dinitrophenol-(DNP) or trinitrophenol-modified mouse spleen cells (SC) induced suppressors in donors able to transfer suppression to normal recipients. When allogeneic DNP-SC were injected into BALB/c mice, cells were generated which were suppressive only in the allogeneic strain providing the DNP-SC. In contrast, when DNP-BALB/c-SC were injected into BALB/c mice, suppressors were generated which were active both in BALB/c and in allogeneic mice (e.g., CBA). This apparent absence of syngeneic major histocompatibility complex restriction may be explained by cross reactive T-cell receptors which are VH gene products.

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
JournalJournal of Experimental Medicine
Volume146
Issue number1
DOIs
StatePublished - Jul 1 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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