Abstract
Genetic restrictions in generation and expression of hapten-specific suppressor cells for contact sensitivity were found. Dinitrophenol-(DNP) or trinitrophenol-modified mouse spleen cells (SC) induced suppressors in donors able to transfer suppression to normal recipients. When allogeneic DNP-SC were injected into BALB/c mice, cells were generated which were suppressive only in the allogeneic strain providing the DNP-SC. In contrast, when DNP-BALB/c-SC were injected into BALB/c mice, suppressors were generated which were active both in BALB/c and in allogeneic mice (e.g., CBA). This apparent absence of syngeneic major histocompatibility complex restriction may be explained by cross reactive T-cell receptors which are VH gene products.
Original language | English (US) |
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Pages (from-to) | 49-58 |
Number of pages | 10 |
Journal | Journal of Experimental Medicine |
Volume | 146 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 1977 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology