@inproceedings{62b75344fd64484ca542291b73b762cf,
title = "Supramolecular delivery of photoactivatable fluorophores in developing embryos",
abstract = "The identification of noninvasive strategies to monitor dynamics within living organisms in real time is essential to elucidate the fundamental factors governing a diversity of biological processes. This study demonstrates that the supramolecular delivery of photoactivatable fluorophores in Drosophila melanogaster embryos allows the real-time tracking of translocating molecules. The designed photoactivatable fluorophores switch from an emissive reactant to an emissive product with spectrally-resolved fluorescence, under moderate blue-light irradiation conditions. These hydrophobic fluorescent probes can be encapsulated within supramolecular hosts and delivered to the cellular blastoderm of the embryos. Thus, the combination of supramolecular delivery and fluorescence photoactivation translates into a noninvasive method to monitor dynamics in vivo and can evolve into a general chemical tool to track motion in biological specimens.",
keywords = "Drosophila Melanogaster, Photoactivation, fluorescence imaging, molecular switches, nanoparticles, self-assembly",
author = "Yang Zhang and Sicheng Tang and Lorenzo Sansalone and Thapaliya, {Ek Raj} and Baker, {James D.} and Raymo, {Fran{\c c}isco M.}",
note = "Funding Information: The National Science Foundation (CHE-1049860) is acknowledged for financial support. Publisher Copyright: {\textcopyright} 2017 SPIE.; Colloidal Nanoparticles for Biomedical Applications XII 2017 ; Conference date: 28-01-2017 Through 31-01-2017",
year = "2017",
doi = "10.1117/12.2261721",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Marek Osinski and Parak, {Wolfgang J.} and Xing-Jie Liang",
booktitle = "Colloidal Nanoparticles for Biomedical Applications XII",
}