Surface-based vector analysis using heat equation interpolation: A new approach to quantify local hippocampal volume changes

Hosung Kim*, Pierre Besson, Olivier Colliot, Andrea Bernasconi, Neda Bernasconi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Scopus citations

Abstract

Analysis of surface-based displacement vectors using spherical harmonic description (SPHARM) localizes shape changes accurately. However, it does not allow differentiating volume variations from shifting and/or bending. We propose a new approach to quantify local volume changes by computing the surface-based Jacobian determinant. This measurement is computed on the displacement vector fields estimated by a heat equation interpolation on the displacement vectors produced by SPHARM. Data simulation showed that the surface-based Jacobian determinant enables accurate quantification of local volume changes without interference of shifting/bending. In patients with temporal lobe epilepsy and left hippocampal atrophy, SPHARM detected widespread inward deformation related to atrophy in the hippocampal head and body, and showed areas of mirrored inward/outward deformations mostly at the level of the hippocampal tail. In these areas, the surface-based Jacobian determinant showed atrophy. Our method facilitates the interpretation of SPHARM because it allows decomposing volume changes and shifting/bending. Furthermore, it provides a better delineation of the extent of hippocampal atrophy.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
Pages1008-1015
Number of pages8
EditionPART 1
DOIs
StatePublished - 2008
Event11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY, United States
Duration: Sep 6 2008Sep 10 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5241 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
CountryUnited States
CityNew York, NY
Period9/6/089/10/08

Keywords

  • Brain morphometry
  • Heat equation
  • Hippocampus
  • Jacobian analysis
  • Shape analysis

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Fingerprint Dive into the research topics of 'Surface-based vector analysis using heat equation interpolation: A new approach to quantify local hippocampal volume changes'. Together they form a unique fingerprint.

Cite this