Surface-enhanced nanosensors

Chanda Ranjit Yonzon, Xiaoyu Zhang, Jing Zhao, Richard P. Van Duyne

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A comparative analysis of the properties of refractive index based detection scheme, localized surface plasmon resonance spectroscopy (LSPR), surface plasmon resonance sensor, and surface-enhanced Raman spectroscopy (SERS) are discussed. SPR reflectivity measurements can be used to characterize the thickness or refractive index of ultrathin organic and biopolymer films at a noble metal surfaces. This type of spectroscopy is widely used in the fields of chemistry and biochemistry to characterize biological surfaces and to monitor binding events. LSPR spectroscopy is a noble metal nanoparticle-based optical sensing technique, effective for quantitative detection of chemical and biological targets. SERS is a vibrational spectroscopic method hat yields unique vibrational signatures for small molecule analytes, as well as quantitative information. Tip-enhanced Raman spectroscopy (TERS) has been developed, which has the potential to provide material, surface and crystallographic generality.

Original languageEnglish (US)
Pages (from-to)42-56
Number of pages15
JournalSpectroscopy (Santa Monica)
Issue number1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Spectroscopy


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