A comparative analysis of the properties of refractive index based detection scheme, localized surface plasmon resonance spectroscopy (LSPR), surface plasmon resonance sensor, and surface-enhanced Raman spectroscopy (SERS) are discussed. SPR reflectivity measurements can be used to characterize the thickness or refractive index of ultrathin organic and biopolymer films at a noble metal surfaces. This type of spectroscopy is widely used in the fields of chemistry and biochemistry to characterize biological surfaces and to monitor binding events. LSPR spectroscopy is a noble metal nanoparticle-based optical sensing technique, effective for quantitative detection of chemical and biological targets. SERS is a vibrational spectroscopic method hat yields unique vibrational signatures for small molecule analytes, as well as quantitative information. Tip-enhanced Raman spectroscopy (TERS) has been developed, which has the potential to provide material, surface and crystallographic generality.
|Original language||English (US)|
|Number of pages||15|
|Journal||Spectroscopy (Santa Monica)|
|State||Published - Jan 2007|
ASJC Scopus subject areas
- Analytical Chemistry
- Atomic and Molecular Physics, and Optics