SURFACE-ENHANCED RAMAN NANOBIOSENSOR

Richard P Van Duyne (Inventor), Matthew R Glucksberg (Inventor), Jay Walsh (Inventor), Nilam C. Shah (Inventor)

Research output: Patent

Abstract

Raman Biosensor for Multianalyte Detection NU 2002-073 Inventors Matthew Glucksberg Richard P Van Duyne* Karen E Shafer-Peltier Christy L Haynes Joseph T Walsh Chanda Ranjit Yonzon Nilam C Shan Olga Lyandres Douglass Stuart Jonathan M Yuen Short Description Novel implantable biosensors for detecting multiple clinically relevant analytes in real time #sensor #biosensor #diagnostics #detection #healthcare Abstract Northwestern University researchers have developed a novel nanoscale biosensor that can be implanted under the skin or in the eye to monitor levels of several clinically important compounds in the blood. This research group has shown that surface- enhanced Raman sensor (SERS) is capable of measuring levels of glucose in vivo, which has historically been a difficult task. Continuous monitoring of blood glucose levels has the potential to reduce the incidence of diabetes related morbidity and mortality and could revolutionize diabetes management by interfacing with implantable insulin pumps. Furthermore, this nanosensor can be modified to detect other compounds in blood, like lactic acid, urea, pesticides and so on. Therefore, many other chronic diseases, like kidney disorders, could be monitored using the same convenient method. Ultimately, devices like this one have the potential to change how clinicians diagnose any number of acute and chronic disorders, as well as help patients manage their symptoms. Applications o Diabetes monitoring and management o Implantable diagnostics Advantages o Sensitive o Small size o Versatile- various analytes can be detected (urea, lactate, pesticides, pollutants etc.) Publications Shafer-Peltier KE, Haynes CL, Glucksberg MR, Van Duyne RP. Toward a Glucose Biosensor Based on Surface-Enhanced Raman Scattering (2003). J. Am. Chem. Soc. 125(2): 588-93. Stuart DA, Yuen JM, Shah N, Lyandres O, Yonzon CR, Glucksberg MR, Walsh JT, Van Duyne RP. In Vivo Glucose Measurement by Surface-Enhanced Raman Spectroscopy (2006). Anal. Chem. 78: 7211-7215. IP Status Issued US patent number 8,592,226. Marketing Contact Allan Nader, PhD Invention Manager (e) a-nader@northwestern.edu (p) 847.491.4456
Original languageEnglish
Patent number8592226
StatePublished - Apr 8 2010

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