Surface-enhanced Raman spectroscopy biosensing: In vivo diagnostics and multimodal imaging

Anne Isabelle Henry, Bhavya Sharma, M. Fernanda Cardinal, Dmitry Kurouski, Richard P. Van Duyne*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations


This perspective presents recent developments in the application of surface-enhanced Raman spectroscopy (SERS) to biosensing, with a focus on in vivo diagnostics. We describe the concepts and methodologies developed to date and the target analytes that can be detected. We also discuss how SERS has evolved from a "point-and-shoot" stand-alone technique in an analytical chemistry laboratory to an integrated quantitative analytical tool for multimodal imaging diagnostics. Finally, we offer a guide to the future of SERS in the context of clinical diagnostics.

Original languageEnglish (US)
Pages (from-to)6638-6647
Number of pages10
JournalAnalytical Chemistry
Issue number13
StatePublished - Jul 5 2016

ASJC Scopus subject areas

  • Analytical Chemistry


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