Abstract
A library of water-soluble dynamic single-chain polymeric nanoparticles (SCPN) was prepared using a controlled radical polymerisation technique followed by the introduction of functional groups, including probes at targeted positions. The combined tools of electron paramagnetic resonance (EPR) and Overhauser dynamic nuclear polarization (ODNP) reveal that these SCPNs have structural and surface hydration properties resembling that of enzymes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2011-2015 |
| Number of pages | 5 |
| Journal | Chemical Science |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2016 |
Funding
P. J. M. S., A. R. A. P. and E. W. M. acknowledge financial support from the Dutch Ministry of Education, Culture and Science (Gravity program 024.001.035) and the European Research Council (FP7/2007-2013, ERC Grant Agreement 246829). C.Y.C. and S.H. acknowledge financial support from the 2011 NIH Director New Innovator Award. This work made use of Materials Research Laboratory Central Facilities supported by NSF through MRSEC (DMR 111053). The MRL is a member of the NSF-funded Material Research Facilities Network (http://www.mrfn.org). This work was funded by the UCSB-CISEI program through the NSF Research Experiences for Undergraduates (NSF DMR 0843934) to L. V. B. and A. C. W. A. J. H. Spiering is acknowledged for synthetic support. The ICMS Animation Studio (Eindhoven University of Technology) is acknowledged for providing the artwork.
ASJC Scopus subject areas
- General Chemistry