Surgery for asymptomatic degenerative aortic and mitral valve disease

Prashant Vaishnava*, Valentin Fuster, Martin Goldman, Robert O. Bonow

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Degenerative valvular heart disease, the most common form of valve disease in the Western world, can lead to aortic stenosis (AS) or mitral regurgitation (MR). In current guidelines for the management of patients with degenerative valvular disease, surgical intervention is recommended at the onset of symptoms or in the presence of left ventricular systolic impairment. Whether surgery is appropriate for asymptomatic patients remains a controversial issue. We argue the case for early pre-emptive intervention in selected, asymptomatic individuals with AS or MR, drawing on contemporary perioperative data, predictors of disease progression, and studies of the natural history of degenerative valvular heart disease.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalNature Reviews Cardiology
Issue number3
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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