Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms

R. Jonas, R. F. Asarnow, C. LoPresti, S. Yudovin, S. Koh, J. Y. Wu, R. Sankar, W. D. Shields, H. V. Vinters, Gary W. Mathern*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Children undergoing surgery with infant-onset epilepsy were classified into those with medically refractory infantile spasms (IS), successfully treated IS, and no IS history, and the groups were compared for pre- and postsurgery clinical and Vineland Adaptive Behavior Scale (VABS) developmental quotients (DQ). Children without an IS history were older at surgery and had longer epilepsy durations than those with IS despite similar substrates, surgeries, and seizure frequencies. In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalNeurology
Volume64
Issue number4
DOIs
StatePublished - Feb 22 2005
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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