Surgical Lung Biopsy for Interstitial Lung Diseases

Rishi Raj*, Kirtee Raparia, David A. Lynch, Kevin K. Brown

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


This review addresses common questions regarding the role of surgical lung biopsy (SLB) in the diagnosis and treatment of interstitial lung disease (ILD). We specifically address when a SLB can be diagnostic as well as when it may be avoided; for example, when the combination of the clinical context and the imaging pattern seen on high-resolution CT (HRCT) chest scans can provide a confident diagnosis. Existing studies on the diagnostic utility as well as the complications associated with SLB are reviewed; also reviewed are the performance characteristics and reliability of HRCT scans of the chest in predicting the underlying histopathologic findings of the lung. The review is formatted in the form of answers to questions that clinicians regularly ask when considering an SLB in a patient with ILD.

Original languageEnglish (US)
Pages (from-to)1131-1140
Number of pages10
Issue number5
StatePublished - May 1 2017


  • idiopathic pulmonary fibrosis
  • interstitial lung disease
  • lung biopsy
  • pulmonary fibrosis
  • surgical lung biopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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