Surgical management of de novo stage IV breast cancer

Jilma Patrick, Seema Ahsan Khan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Management of the intact primary tumor in women presenting with stage IV breast cancer has classically been determined by the presence or absence of symptoms. However, multiple retrospective reviews completed over the past decade suggest a survival advantage with resection of the intact, asymptomatic primary tumor in these women. These reviews are not without bias, and recently completed randomized trials do not support a significant survival benefit, although local control benefits may exist. Completion of ongoing trials is needed to reach a definitive conclusion regarding the merit of primary tumor resection for local control and survival. Until unbiased data are available, local therapy for the asymptomatic primary cannot be routinely recommended, but may be considered in selected individuals, with multidisciplinary input, when systemic disease is well controlled.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue number4
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Oncology


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