Surgical treatment and long-term neurodevelopmental outcome for infants with idiopathic aqueductal stenosis

William C. Hanigan*, Andrew Morgan, Aimen Shaaban, Patricia Bradle

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Evaluation of in utero shunting for fetal ventriculomegaly requires an analysis of the ex utero treatment of a comparison population of infants with idiopathic aqueductal stenosis (IAS). In this study, 14 neonates with IAS were followed with detailed developmental assessment profiles for 18 months or longer. Using magnetic resonance imaging, the preoperative and postoperative frontal cortical mantle widths (FCMW) were determined for each patient. Four of 14 children demonstrated normal outcomes while 5 of 14 children showed abnormal outcomes. The remaining 5 children demonstrated minimally impaired outcomes. No child with a postoperative FCMW below 30 mm showed normal development on any scale, while all children with abnormal development demonstrated a postoperative FCMW of 21 mm or less. In conclusion, the prognosis for normal long-term neurodevelopment in infants with IAS, despite prompt ex utero treatment, is guarded; the majority of such children will show developmental delays of varying degreès. The FCMW serves as a reasonable prognostic indicator in this patient population.

Original languageEnglish (US)
Pages (from-to)386-390
Number of pages5
JournalChild's Nervous System
Volume7
Issue number7
DOIs
StatePublished - Nov 1 1991

Keywords

  • Aqueductal stenosis
  • Hydrocephalus
  • Neurodevelopmental outcome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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