Surgical Treatment of Parkinson’s Disease

Leo Verhagen Metman*, Gian Pal, Konstantin Slavin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Deep brain stimulation is now an established therapy for Parkinson’s disease, and DBS continues to be refined. Well-established targets, such as the STN and GPi, have shown clear benefit in reducing motor complications in PD, and other more novel targets, such as PPN are being explored. Furthermore, there have been advances in imaging which allow for improved lead placement and also can reduce patient discomfort. The way electrical current is delivered through the DBS lead is also undergoing a transformation, allowing for more options regarding current shaping, steering, and new stimulation paradigms. The future holds promise for novel methodologies of neuromodulation including closed-loop devices and more focused lesion therapies that alter CNS circuitry.

Original languageEnglish (US)
Article number49
JournalCurrent Treatment Options in Neurology
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • Closed loop
  • Current steering
  • DBS
  • Focused ultrasound
  • Intraoperative imaging
  • Stereotactic surgery

ASJC Scopus subject areas

  • Clinical Neurology

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