Surgical treatment of patients with lobar holoprosencephaly: A personal note

Jay M. Pensler*, Sharon Giese, Joel Charrow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The diagnosis of holoprosencephaly usually implies a poor prognosis and is often regarded as a contraindication for surgical correction of associated clefts of the lip or palate. Between 1985 and 1991, 4 patients with lobar holoprosencephaly were evaluated and studied with computed tomography or magnetic resonance imaging. All had cleft palate and 3 had paramedian cleft lip; all 4 exhibited some degree of nasal dysplasia. All patients are presently alive, at a mean age of 26.6 ± 2.4 months (mean ± SD). Three of the children showed normal or near normal development, whereas the fourth was severely retarded. Our experience suggests that some children with lobar holoprosencephaly have a highly variable degree of intellectual development and that long-term survival may be expected.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalJournal of Craniofacial Surgery
Issue number1
StatePublished - Jan 1993


  • Holoprosencephaly
  • Surgical treatment

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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