Surplus sterols suppress Salmonella-specific IgA

Elise G. Liu; Stephanie C. Eisenbarth

doi:10.1126/SCIIMMUNOL.ABN3793

Surplus sterols suppress Salmonella-specific IgA

Elise G. Liu, Stephanie C. Eisenbarth

Medicine, Allergy Division

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Dietary cholesterol is metabolized into 25-hydroxycholesterol, which decreases intestinal IgA responses by reducing the expression of sterol-sensing transcription factor SREBP2, thereby preventing IgA plasma cell differentiation.

Original language	English (US)
Journal	Science Immunology
Volume	6
Issue number	66
DOIs	https://doi.org/10.1126/SCIIMMUNOL.ABN3793
State	Published - Dec 2021

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1126/SCIIMMUNOL.ABN3793

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title = "Surplus sterols suppress Salmonella-specific IgA",

abstract = "Dietary cholesterol is metabolized into 25-hydroxycholesterol, which decreases intestinal IgA responses by reducing the expression of sterol-sensing transcription factor SREBP2, thereby preventing IgA plasma cell differentiation.",

author = "Liu, {Elise G.} and Eisenbarth, {Stephanie C.}",

year = "2021",

month = dec,

doi = "10.1126/SCIIMMUNOL.ABN3793",

language = "English (US)",

volume = "6",

journal = "Science Immunology",

issn = "2470-9468",

publisher = "American Association for the Advancement of Science",

number = "66",

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T1 - Surplus sterols suppress Salmonella-specific IgA

AU - Liu, Elise G.

AU - Eisenbarth, Stephanie C.

PY - 2021/12

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N2 - Dietary cholesterol is metabolized into 25-hydroxycholesterol, which decreases intestinal IgA responses by reducing the expression of sterol-sensing transcription factor SREBP2, thereby preventing IgA plasma cell differentiation.

AB - Dietary cholesterol is metabolized into 25-hydroxycholesterol, which decreases intestinal IgA responses by reducing the expression of sterol-sensing transcription factor SREBP2, thereby preventing IgA plasma cell differentiation.

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SN - 2470-9468

VL - 6

JO - Science Immunology

JF - Science Immunology

IS - 66

ER -

Surplus sterols suppress Salmonella-specific IgA

Abstract

ASJC Scopus subject areas

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