Survey of ferroxidase expression and siderophore production in clinical isolates of Pseudomonas aeruginosa

Wilhelmina M. Huston; Adam J. Potter; Michael P. Jennings; Jordi Rello; Alan R. Hauser; Alastair G. McEwan

doi:10.1128/JCM.42.6.2806-2809.2004

Survey of ferroxidase expression and siderophore production in clinical isolates of Pseudomonas aeruginosa

Wilhelmina M. Huston, Adam J. Potter, Michael P. Jennings^*, Jordi Rello, Alan R. Hauser, Alastair G. McEwan

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Ferroxidase (encoded by the mco gene), a component of a ferrous iron uptake pathway in Pseudomonas aeruginosa, was detected in all of the 35 respiratory clinical isolates surveyed; in contrast, considerable variation in siderophore expression was observed. The ubiquitous expression of this periplasmic ferroxidase suggests that it plays a key role in iron uptake in this opportunistic pathogen.

Original language	English (US)
Pages (from-to)	2806-2809
Number of pages	4
Journal	Journal of clinical microbiology
Volume	42
Issue number	6
DOIs	https://doi.org/10.1128/JCM.42.6.2806-2809.2004
State	Published - Jun 2004

ASJC Scopus subject areas

Microbiology (medical)

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abstract = "Ferroxidase (encoded by the mco gene), a component of a ferrous iron uptake pathway in Pseudomonas aeruginosa, was detected in all of the 35 respiratory clinical isolates surveyed; in contrast, considerable variation in siderophore expression was observed. The ubiquitous expression of this periplasmic ferroxidase suggests that it plays a key role in iron uptake in this opportunistic pathogen.",

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AU - Rello, Jordi

AU - Hauser, Alan R.

AU - McEwan, Alastair G.

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AB - Ferroxidase (encoded by the mco gene), a component of a ferrous iron uptake pathway in Pseudomonas aeruginosa, was detected in all of the 35 respiratory clinical isolates surveyed; in contrast, considerable variation in siderophore expression was observed. The ubiquitous expression of this periplasmic ferroxidase suggests that it plays a key role in iron uptake in this opportunistic pathogen.

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