TY - JOUR
T1 - Surveying macrocyclic chemistry
T2 - From flexible crown ethers to rigid cyclophanes
AU - Liu, Zhichang
AU - Nalluri, Siva Krishna Mohan
AU - Fraser Stoddart, J.
N1 - Funding Information:
This work is part of the Joint Center of Excellence in Integrated Nano-Systems (JCIN) at King Abdulaziz City for Science and Technology (KACST) and Northwestern University (NU). The authors would like to thank both KACST and NU for their continued support of this work.
Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017/5/7
Y1 - 2017/5/7
N2 - Macrocycles are molecular entities that display a combination of molecular recognition and complexation properties with vital implications for host-guest/supramolecular chemistry. Since the accidental discovery of the crown ethers by Pedersen half a century ago, the chemistry of wholly synthetic macrocycles for structure-specific, highly selective, host-guest complexation has experienced rapid development. While the structural diversity and host-guest chemistry of the original macrocycles are well-known, new derivatives of them are being investigated continuously and reported on today in order to improve their recognition properties as well as to unleash new opportunities in supramolecular chemistry. In this Review, we survey the recent developments of the chemistry of naturally occurring cyclodextrins, along with a variety of synthetic flexible and rigid macrocycles that have drawn their inspiration from Pedersen's ground-breaking discovery of crown ethers in the mid-1960s.
AB - Macrocycles are molecular entities that display a combination of molecular recognition and complexation properties with vital implications for host-guest/supramolecular chemistry. Since the accidental discovery of the crown ethers by Pedersen half a century ago, the chemistry of wholly synthetic macrocycles for structure-specific, highly selective, host-guest complexation has experienced rapid development. While the structural diversity and host-guest chemistry of the original macrocycles are well-known, new derivatives of them are being investigated continuously and reported on today in order to improve their recognition properties as well as to unleash new opportunities in supramolecular chemistry. In this Review, we survey the recent developments of the chemistry of naturally occurring cyclodextrins, along with a variety of synthetic flexible and rigid macrocycles that have drawn their inspiration from Pedersen's ground-breaking discovery of crown ethers in the mid-1960s.
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U2 - 10.1039/c7cs00185a
DO - 10.1039/c7cs00185a
M3 - Review article
C2 - 28462968
AN - SCOPUS:85021818329
SN - 0306-0012
VL - 46
SP - 2459
EP - 2478
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 9
ER -