Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors

Lori E. Weinberg, John R. Lurain, Diljeet K. Singh, Julian C. Schink

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Objective: The objective of this study is to review all malignant germ-cell tumors (MOGCTs) treated at our institution, focusing on reproductive outcomes and menstrual function of patients treated with fertility-sparing surgery and adjuvant chemotherapy. Methods: We performed a retrospective chart review of patients treated for MOGCTs between January 1, 1979 and March 31, 2008. Charts of identified patients were abstracted and data were collected. Patients who had fertility-sparing surgery were contacted and a telephone questionnaire was performed to gather reproductive and menstrual history. Results: Forty patients were treated for MOGCTs at our institution. Mean age at the time of diagnosis was 26.5 years (range, 10-48 years). Histologic subtypes were: immature teratoma (52.5%), dysgerminoma (27.5%), yolk sac tumor (10.0%), mixed germ cell tumor (7.5%), and choriocarcinoma (2.5%). Thirty-five percent of tumors were FIGO stages II-IV. Twenty-seven patients (67.5%) were treated with chemotherapy postoperatively, 23 (85%) of whom received bleomycin, etoposide and cisplatin (BEP). There were three recurrences, but no deaths. Fertility-sparing surgery was performed in 22 patients (55%), 16 of whom received adjuvant chemotherapy. Fourteen of these patients were contacted. Of the 10 remaining patients desiring pregnancy, 8 (80%) had 11 successful spontaneous pregnancies, one required in-vitro fertilization, and the other required donor egg in-vitro fertilization, resulting in 14 live births. All 14 patients had normal menstrual cycles within one year of completing chemotherapy. Conclusions: Overall survival was 100% among patients with both local and advanced MOGCTs, including those who underwent fertility-sparing surgery. Fertility-sparing surgery plus adjuvant chemotherapy appeared to have little or no effect on fertility or menstrual cycles.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalGynecologic oncology
Issue number2
StatePublished - May 1 2011


  • Chemotherapy
  • Fertility
  • Malignant ovarian germ cell tumors
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors'. Together they form a unique fingerprint.

Cite this