Survivin: An inhibitor of apoptosis in pediatric cancer

Jason R. Fangusaro; Hugo Caldas; Yuying Jiang; Rachel A. Altura

doi:10.1002/pbc.20805

Survivin: An inhibitor of apoptosis in pediatric cancer

Jason R. Fangusaro, Hugo Caldas, Yuying Jiang, Rachel A. Altura^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Survivin is an inhibitor of apoptosis protein (IAP) expressed in a large number of adult malignancies. Its expression levels correlate with more aggressive disease and poor clinical outcome in many of these tumors. As its expression is restricted in normal adult differentiated tissues, it has become of great interest as both a tumor prognostic marker and as a potential biologic target for future anticancer therapies. Survivin expression and Survivin-based therapies have been examined in many of the more common pediatric malignancies. We present an overview of Survivin function and current research exploring its biologic and therapeutic roles in pediatric tumors.

Original language	English (US)
Pages (from-to)	4-13
Number of pages	10
Journal	Pediatric Blood and Cancer
Volume	47
Issue number	1
DOIs	https://doi.org/10.1002/pbc.20805
State	Published - Jul 2006

Keywords

Apoptosis
Cancer
Children
Survivin
Therapy
Tumor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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title = "Survivin: An inhibitor of apoptosis in pediatric cancer",

abstract = "Survivin is an inhibitor of apoptosis protein (IAP) expressed in a large number of adult malignancies. Its expression levels correlate with more aggressive disease and poor clinical outcome in many of these tumors. As its expression is restricted in normal adult differentiated tissues, it has become of great interest as both a tumor prognostic marker and as a potential biologic target for future anticancer therapies. Survivin expression and Survivin-based therapies have been examined in many of the more common pediatric malignancies. We present an overview of Survivin function and current research exploring its biologic and therapeutic roles in pediatric tumors.",

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T2 - An inhibitor of apoptosis in pediatric cancer

AU - Fangusaro, Jason R.

AU - Caldas, Hugo

AU - Jiang, Yuying

AU - Altura, Rachel A.

PY - 2006/7

Y1 - 2006/7

N2 - Survivin is an inhibitor of apoptosis protein (IAP) expressed in a large number of adult malignancies. Its expression levels correlate with more aggressive disease and poor clinical outcome in many of these tumors. As its expression is restricted in normal adult differentiated tissues, it has become of great interest as both a tumor prognostic marker and as a potential biologic target for future anticancer therapies. Survivin expression and Survivin-based therapies have been examined in many of the more common pediatric malignancies. We present an overview of Survivin function and current research exploring its biologic and therapeutic roles in pediatric tumors.

AB - Survivin is an inhibitor of apoptosis protein (IAP) expressed in a large number of adult malignancies. Its expression levels correlate with more aggressive disease and poor clinical outcome in many of these tumors. As its expression is restricted in normal adult differentiated tissues, it has become of great interest as both a tumor prognostic marker and as a potential biologic target for future anticancer therapies. Survivin expression and Survivin-based therapies have been examined in many of the more common pediatric malignancies. We present an overview of Survivin function and current research exploring its biologic and therapeutic roles in pediatric tumors.

KW - Apoptosis

KW - Cancer

KW - Children

KW - Survivin

KW - Therapy

KW - Tumor

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DO - 10.1002/pbc.20805

M3 - Review article

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JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

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Survivin: An inhibitor of apoptosis in pediatric cancer

Abstract

Keywords

ASJC Scopus subject areas

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