Susceptibility and resistance to poliovirus-induced paralysis of inbred mouse strains

B. Jubelt*, S. L. Ropka, S. Goldfarb, C. Waltenbaugh, R. P. Oates

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Susceptibility to human poliovirus-induced disease in different inbred mouse strains was analyzed after intracerebral inoculation of two mouse-adapted type 2 polioviruses, the attenuated W-2 strain and the virulent Lansing strain. In contrast to inoculation with the Lansing strain, which was invariably lethal, inoculation with the W-2 strain defined three groups of mice with high, intermediate, or low disease incidence. Those in the high-disease-incidence group, the DBA/1J and DBA/2J mice, exhibited a high level of virus replication in the spinal cord by day 2 postinfection, with no detectable neutralizing-antibody response. Mice in the intermediate- and low-incidence groups had lower levels of virus replication in the spinal cord and/or produced neutralizing antibodies. No correlation was observed between H-2 haplotype and the extent of virus replication, production of neutralizing or enzyme-linked immunosorbent assay-detectable antibodies, or T-cell-proliferative response. However, mice of the H-2(k) haplotype manifested a low incidence of disease.

Original languageEnglish (US)
Pages (from-to)1035-1040
Number of pages6
JournalJournal of virology
Volume65
Issue number2
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Jubelt, B., Ropka, S. L., Goldfarb, S., Waltenbaugh, C., & Oates, R. P. (1991). Susceptibility and resistance to poliovirus-induced paralysis of inbred mouse strains. Journal of virology, 65(2), 1035-1040. https://doi.org/10.1128/jvi.65.2.1035-1040.1991