Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis

Samuel M. Behar*, Chris C. Dascher, Michael J. Grusby, Chyung Ru Wang, Michael B. Brenner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

283 Scopus citations

Abstract

Cellular immunity against Mycobacterium tuberculosis controls infection in the majority of infected humans. Studies in mice have delineated an important role for CD4+ T cells and cytokines including interferon γ and tumor necrosis factor α in the response to infection with mycobacteria. Recently, the identification of CD8+ CD1-restricted T cells that kill M. tuberculosis organisms via granulysin and the rapid death after infection of β2 microglobulin deficient mice in humans has drawn attention to a critical role for CD8+ T cells. The nature of mycobacterial-specific CD8+ T cells has been an enigma because few have been identified in any species. Here, we delineate the contribution of class I MHC-restricted T cells in the defense against tuberculosis as transporter associated with antigen processing (TAP)1-deficient mice died rapidly, bore a greater bacterial burden, and had more severe tissue pathology than control mice. In contrast, CD1D(-/-) mice were not significantly different in their susceptibility to infection than control mice. This data demonstrates a critical role for TAP-dependent peptide antigen presentation and provides further evidence that class I MHC- restricted CD8+ T cells, the major T cell subset activated by this antigen processing pathway, play an essential role in immunity to tuberculosis.

Original languageEnglish (US)
Pages (from-to)1973-1980
Number of pages8
JournalJournal of Experimental Medicine
Volume189
Issue number12
DOIs
StatePublished - Jun 21 1999

Keywords

  • CD1
  • CD8
  • Infection
  • Mycobacterium tuberculosis
  • Transporter associated with antigen processing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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