Abstract
This study investigated cross-sectional associations of peripheral artery disease (PAD) severity (defined by the ankle–brachial index (ABI)) and amounts of daily sustained physical activity (PA) (defined as > 100 activity counts per minute lasting 5 consecutive minutes or more). This study also investigated associations of amounts of daily sustained PA with 6-minute walk (6MW) distance and the Short Form-36 physical functioning domain (SF-36 PF) score in cross-sectional analyses and with serious adverse events (SAEs) in longitudinal analyses of people with PAD. PA was measured continuously for 10 days using a tri-axial accelerometer at baseline in 277 participants with PAD randomized to the LITE clinical trial. In regression analyses, each 0.15 lower ABI value was associated with a 5.67% decrease in the number of daily bouts of sustained PA (95% CI: 3.85–6.54; p < 0.001). Every additional bout of sustained PA per day was associated with a 4.56-meter greater 6MW distance (95% CI: 2.67–6.46; p < 0.0001), and a 0.81-point improvement in SF-36 PF score (95% CI: 0.34–1.28; p < 0.001). Participants with values of daily bouts of sustained PA below the median had higher rates of SAEs during follow-up, compared to participants above the median (41% vs 24%; p = 0.002). In conclusion, among participants with PAD, lower ABI values were associated with fewer bouts of daily sustained PA. A greater number of bouts of daily sustained PA were associated with better 6MW performance and SF-36 PF score, and, in longitudinal analyses, lower rates of SAEs. Clinicaltrials.gov ID: NCT02538900.
Original language | English (US) |
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Pages (from-to) | 497-506 |
Number of pages | 10 |
Journal | Vascular Medicine (United Kingdom) |
Volume | 26 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2021 |
Funding
Dr. McDermott reports a research grant from Regeneron and other research support from Helixmith, Chromadex, Mars, ReserveAge, Hershey, and ArtAssist. The remaining authors have nothing to disclose.
Keywords
- ankle–brachial index (ABI)
- atherosclerosis
- peripheral artery disease (PAD)
- six-minute walk
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial
Slysz, J. T. (Creator), Rejeski, W. J. (Contributor), Treat-Jacobson, D. (Creator), Bazzano, L. A. (Creator), Forman, D. E. (Creator), Manini, T. M. (Creator), Criqui, M. H. (Creator), Tian, L. (Creator), Zhao, L. (Contributor), Zhang, D. (Contributor), Guralnik, J. M. (Creator), Ferrucci, L. (Creator), Kibbe, M. R. (Creator), Polonsky, T. S. (Creator), Spring, B. (Creator), Sufit, R. (Creator), Leeuwenburgh, C. (Creator) & McDermott, M. M. (Creator), SAGE Journals, 2021
DOI: 10.25384/sage.c.5370594, https://sage.figshare.com/collections/Sustained_physical_activity_in_peripheral_artery_disease_Associations_with_disease_severity_functional_performance_health-related_quality_of_life_and_subsequent_serious_adverse_events_in_the_LITE_randomized_clinical_trial/5370594
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