Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial

Joshua T. Slysz, W. Jack Rejeski, Diane Treat-Jacobson, Lydia A. Bazzano, Daniel E. Forman, Todd M. Manini, Michael H. Criqui, Lu Tian, Lihui Zhao, Dongxue Zhang, Jack M. Guralnik, Luigi Ferrucci, Melina R. Kibbe, Tamar S. Polonsky, Bonnie Spring, Robert Sufit, Christiaan Leeuwenburgh, Mary M. McDermott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated cross-sectional associations of peripheral artery disease (PAD) severity (defined by the ankle–brachial index (ABI)) and amounts of daily sustained physical activity (PA) (defined as > 100 activity counts per minute lasting 5 consecutive minutes or more). This study also investigated associations of amounts of daily sustained PA with 6-minute walk (6MW) distance and the Short Form-36 physical functioning domain (SF-36 PF) score in cross-sectional analyses and with serious adverse events (SAEs) in longitudinal analyses of people with PAD. PA was measured continuously for 10 days using a tri-axial accelerometer at baseline in 277 participants with PAD randomized to the LITE clinical trial. In regression analyses, each 0.15 lower ABI value was associated with a 5.67% decrease in the number of daily bouts of sustained PA (95% CI: 3.85–6.54; p < 0.001). Every additional bout of sustained PA per day was associated with a 4.56-meter greater 6MW distance (95% CI: 2.67–6.46; p < 0.0001), and a 0.81-point improvement in SF-36 PF score (95% CI: 0.34–1.28; p < 0.001). Participants with values of daily bouts of sustained PA below the median had higher rates of SAEs during follow-up, compared to participants above the median (41% vs 24%; p = 0.002). In conclusion, among participants with PAD, lower ABI values were associated with fewer bouts of daily sustained PA. A greater number of bouts of daily sustained PA were associated with better 6MW performance and SF-36 PF score, and, in longitudinal analyses, lower rates of SAEs. Clinicaltrials.gov ID: NCT02538900.

Original languageEnglish (US)
JournalVascular Medicine (United Kingdom)
DOIs
StateAccepted/In press - 2021

Keywords

  • ankle–brachial index (ABI)
  • atherosclerosis
  • peripheral artery disease (PAD)
  • six-minute walk

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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