Swallowing and speech ability after treatment for head and neck cancer with targeted intraarterial versus intravenous chemoradiation

Lisa A. Newman, K. Thomas Robbins, Jeri A. Logemann*, Alfred W. Rademaker, Cathy L. Lazarus, Annette Hamner, Stephanie Tusant, Cheng Fang Huang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Objective. RADPLAT (concurrent selective supradose intraarterial cisplatin and external-beam irradiation) delivers extraordinarily high cisplatin concentration to head and neck structures. This study was designed to quantify and compare RADPLAT and systemic chemoradiation treatment effects on swallowing and speech. Methods. Videofluorographic swallowing studies and articulation testing of 14 head and neck cancer patients treated with RADPLAT were compared with 16 treated with systemic chemoradiation 1 month after treatment. Results. RADPLAT and systemic chemoradiation patients did not differ significantly on most swallow outcome measures, and there was significantly less aspiration on 1 and 3 mL liquid for RADPLAT individuals. Speech function was comparable except for RADPLAT's significantly worse /s, z/ productions. Conclusions. Increased concentration of cisplatin to the head and neck did not result in generally reduced swallowing or articulatory function.

Original languageEnglish (US)
Pages (from-to)68-77
Number of pages10
JournalHead and Neck
Volume24
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Cisplatin
  • Dysphagia
  • RADPLAT
  • Swallowing
  • Videofluorography

ASJC Scopus subject areas

  • Otorhinolaryngology

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