Swept-source visible-light optical coherence tomography

Weijia Fan; Roman Kuranov; David A. Miller; Tingwei Zhang; Wei Hong Yeo; Raymond Atkinson; Pengpeng Zhang; Cheng Sun; Hao F. Zhang

doi:10.1364/OL.544499

Swept-source visible-light optical coherence tomography

Weijia Fan, Roman Kuranov, David A. Miller, Tingwei Zhang, Wei Hong Yeo, Raymond Atkinson, Pengpeng Zhang, Cheng Sun, Hao F. Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). We used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert a commercial near-infrared swept-source (NIR-SS) laser into a visible-light SS laser. To enhance SHG efficiency, we amplified the NIR-SS output with booster optical amplifiers (BOAs) and generated up to 580 µW of power. The SS-vis-OCT achieved a maximum axial resolution of 7.3 µm and an imaging depth of 5 mm in air, corresponding to 5.4 µm and 3.7 mm in tissue (n = 1.35). Compared with spectral-domain vis-OCT, SS-vis-OCT provides a 2.2-fold increased imaging depth and a 2.8-fold improved roll-off. Additionally, we validated SS-vis-OCT performance using a 3D-printed pyramid phantom, with its feature measurements cross-validated by scanning electron microscopy (SEM).

Original language	English (US)
Pages (from-to)	928-931
Number of pages	4
Journal	Optics Letters
Volume	50
Issue number	3
DOIs	https://doi.org/10.1364/OL.544499
State	Published - Feb 1 2025

Funding

National Institutes of Health (R43EY034800, U01EY033001); Christina Enroth-Cugell Graduate Research Award.

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OL.544499

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title = "Swept-source visible-light optical coherence tomography",

abstract = "We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). We used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert a commercial near-infrared swept-source (NIR-SS) laser into a visible-light SS laser. To enhance SHG efficiency, we amplified the NIR-SS output with booster optical amplifiers (BOAs) and generated up to 580 µW of power. The SS-vis-OCT achieved a maximum axial resolution of 7.3 µm and an imaging depth of 5 mm in air, corresponding to 5.4 µm and 3.7 mm in tissue (n = 1.35). Compared with spectral-domain vis-OCT, SS-vis-OCT provides a 2.2-fold increased imaging depth and a 2.8-fold improved roll-off. Additionally, we validated SS-vis-OCT performance using a 3D-printed pyramid phantom, with its feature measurements cross-validated by scanning electron microscopy (SEM).",

author = "Weijia Fan and Roman Kuranov and Miller, \{David A.\} and Tingwei Zhang and Yeo, \{Wei Hong\} and Raymond Atkinson and Pengpeng Zhang and Cheng Sun and Zhang, \{Hao F.\}",

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AU - Fan, Weijia

AU - Kuranov, Roman

AU - Miller, David A.

AU - Zhang, Tingwei

AU - Yeo, Wei Hong

AU - Atkinson, Raymond

AU - Zhang, Pengpeng

AU - Sun, Cheng

AU - Zhang, Hao F.

PY - 2025/2/1

Y1 - 2025/2/1

N2 - We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). We used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert a commercial near-infrared swept-source (NIR-SS) laser into a visible-light SS laser. To enhance SHG efficiency, we amplified the NIR-SS output with booster optical amplifiers (BOAs) and generated up to 580 µW of power. The SS-vis-OCT achieved a maximum axial resolution of 7.3 µm and an imaging depth of 5 mm in air, corresponding to 5.4 µm and 3.7 mm in tissue (n = 1.35). Compared with spectral-domain vis-OCT, SS-vis-OCT provides a 2.2-fold increased imaging depth and a 2.8-fold improved roll-off. Additionally, we validated SS-vis-OCT performance using a 3D-printed pyramid phantom, with its feature measurements cross-validated by scanning electron microscopy (SEM).

AB - We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). We used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert a commercial near-infrared swept-source (NIR-SS) laser into a visible-light SS laser. To enhance SHG efficiency, we amplified the NIR-SS output with booster optical amplifiers (BOAs) and generated up to 580 µW of power. The SS-vis-OCT achieved a maximum axial resolution of 7.3 µm and an imaging depth of 5 mm in air, corresponding to 5.4 µm and 3.7 mm in tissue (n = 1.35). Compared with spectral-domain vis-OCT, SS-vis-OCT provides a 2.2-fold increased imaging depth and a 2.8-fold improved roll-off. Additionally, we validated SS-vis-OCT performance using a 3D-printed pyramid phantom, with its feature measurements cross-validated by scanning electron microscopy (SEM).

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Swept-source visible-light optical coherence tomography

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