Switching gears during T-cell maturation: RANTES and late transcription

Benjamin D. Ortiz; Peter J. Nelson; Alan M. Krensky

doi:10.1016/S0167-5699(97)01128-6

Switching gears during T-cell maturation: RANTES and late transcription

Benjamin D. Ortiz^*, Peter J. Nelson, Alan M. Krensky

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Abstract

Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post- stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.

Original language	English (US)
Pages (from-to)	468-471
Number of pages	4
Journal	Immunology Today
Volume	18
Issue number	10
DOIs	https://doi.org/10.1016/S0167-5699(97)01128-6
State	Published - Oct 1997

ASJC Scopus subject areas

Immunology

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10.1016/S0167-5699(97)01128-6

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title = "Switching gears during T-cell maturation: RANTES and late transcription",

abstract = "Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post- stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.",

author = "Ortiz, {Benjamin D.} and Nelson, {Peter J.} and Krensky, {Alan M.}",

year = "1997",

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T2 - RANTES and late transcription

AU - Ortiz, Benjamin D.

AU - Nelson, Peter J.

AU - Krensky, Alan M.

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Y1 - 1997/10

N2 - Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post- stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.

AB - Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post- stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.

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ER -

Switching gears during T-cell maturation: RANTES and late transcription

Abstract

ASJC Scopus subject areas

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