Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Blanca Noriega Esquives; Tae K. Lee; Patricia I. Moreno; Rina S. Fox; Betina Yanez; Gregory E. Miller; Ryne Estabrook; Mark J. Begale; Sarah C. Flury; Kent Perry; Shilajit D. Kundu; Frank J. Penedo

doi:10.1007/s10865-022-00288-4

Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Blanca Noriega Esquives^*, Tae K. Lee, Patricia I. Moreno, Rina S. Fox, Betina Yanez, Gregory E. Miller, Ryne Estabrook, Mark J. Begale, Sarah C. Flury, Kent Perry, Shilajit D. Kundu, Frank J. Penedo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: “high symptom burden,” “high sexual bother,” and “low symptom burden.” Men with “high symptom burden” were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with “high symptom burden” also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.

Original language	English (US)
Pages (from-to)	366-377
Number of pages	12
Journal	Journal of Behavioral Medicine
Volume	45
Issue number	3
DOIs	https://doi.org/10.1007/s10865-022-00288-4
State	Published - Jun 2022

Funding

This study was supported by a National Cancer Institute grant (R01CA157809) awarded to Dr. Frank Penedo. Dr. Rina Fox was supported by the National Cancer Institute under grant number K08CA247973.

Keywords

Androgen deprivation therapy
Latent profile analysis
Prostate cancer
Psychosocial well-being
Quality of life
Symptom burden

ASJC Scopus subject areas

General Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10865-022-00288-4

Cite this

Noriega Esquives, B., Lee, T. K., Moreno, P. I., Fox, R. S., Yanez, B., Miller, G. E., Estabrook, R., Begale, M. J., Flury, S. C., Perry, K., Kundu, S. D., & Penedo, F. J. (2022). Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy. Journal of Behavioral Medicine, 45(3), 366-377. https://doi.org/10.1007/s10865-022-00288-4

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title = "Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy",

abstract = "To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: “high symptom burden,” “high sexual bother,” and “low symptom burden.” Men with “high symptom burden” were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with “high symptom burden” also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.",

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author = "{Noriega Esquives}, Blanca and Lee, {Tae K.} and Moreno, {Patricia I.} and Fox, {Rina S.} and Betina Yanez and Miller, {Gregory E.} and Ryne Estabrook and Begale, {Mark J.} and Flury, {Sarah C.} and Kent Perry and Kundu, {Shilajit D.} and Penedo, {Frank J.}",

note = "Funding Information: This study was supported by a National Cancer Institute grant (R01CA157809) awarded to Dr. Frank Penedo. Dr. Rina Fox was supported by the National Cancer Institute under grant number K08CA247973. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Penedo, Frank J.

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N2 - To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: “high symptom burden,” “high sexual bother,” and “low symptom burden.” Men with “high symptom burden” were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with “high symptom burden” also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.

AB - To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: “high symptom burden,” “high sexual bother,” and “low symptom burden.” Men with “high symptom burden” were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with “high symptom burden” also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.

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Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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