TY - JOUR
T1 - Symptomatology and cognitive impairment associate independently with post-dexamethasone cortisol concentrations in unmedicated schizophrenic patients
AU - Newcomer, John W.
AU - Faustman, William O.
AU - Whiteford, Harvey A.
AU - Moses, James A.
AU - Csernansky, John G.
PY - 1991/5/1
Y1 - 1991/5/1
N2 - Serum cortisol concentrations were measured after dexamethasone administration (1 mg) in 21 neuroleptic-free schizophrenic inpatients. Patients were assessed using the Brief Psychiatric Rating Scale and a battery of cognitive tests. A significant correlation was found between negative symptoms and both 8:00 AM and 4:00 PM post-dexamethasone cortisol concentration (PDC). Cognitive impairment on several measures was also correlated with 8 AM PDC, but in an independent manner. Although positive and negative symptoms were unrelated, exploratory analysis revealed a significant inverse correlation between a positive symptom grouping and both 8:00 AM and 4:00 PM PDC.
AB - Serum cortisol concentrations were measured after dexamethasone administration (1 mg) in 21 neuroleptic-free schizophrenic inpatients. Patients were assessed using the Brief Psychiatric Rating Scale and a battery of cognitive tests. A significant correlation was found between negative symptoms and both 8:00 AM and 4:00 PM post-dexamethasone cortisol concentration (PDC). Cognitive impairment on several measures was also correlated with 8 AM PDC, but in an independent manner. Although positive and negative symptoms were unrelated, exploratory analysis revealed a significant inverse correlation between a positive symptom grouping and both 8:00 AM and 4:00 PM PDC.
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U2 - 10.1016/0006-3223(91)90052-N
DO - 10.1016/0006-3223(91)90052-N
M3 - Article
C2 - 2049484
AN - SCOPUS:0025797259
SN - 0006-3223
VL - 29
SP - 855
EP - 864
JO - Biological psychiatry
JF - Biological psychiatry
IS - 9
ER -