Symptoms of Lower Urinary Tract Dysfunction Research Network

Claire C. Yang, Kevin P. Weinfurt, Robert M. Merion, Ziya Kirkali, Cindy Amundsen, Kevin Weinfurt, Kathryn Flynn, Matthew O. Fraser, Todd Harshbarger, Drew Peterson, Xavier A. Preud'homme, Nazema Siddiqui, George Webster, Carrie Dombeck, Robin Gilliam, Akira Hayes, Nicole Longoria, Shantae McLean, Karl Kreder, Catherine S. BradleyBradley A. Erickson, Susan K. Lutgendorf, Vince Magnotta, Michael A. O'Donnell, Vivian Sung, Linda Moss, Andrea Lopez, David Cella, Brian T. Helfand, James Griffith, John C. Hairston, Kimberly Kenton, Todd Parrish, Jennie Yu Fan Chan, Alexandria Alverdy, Sarah Buono, Maria Corona, Jasmine Nero, Pooja Talaty, Veronica Venezuela, J. Quentin Clemens, Mitch Berger, John DeLancey, Dee Fenner, Rick Harris, Steve Harte, Anne Pelletier-Cameron, John Wei, Linda Drnek, Nina Dutta, LURN Study Group, LURN Study Group

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose To address gaps in understanding and treating lower urinary tract symptoms, the NIDDK created the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The goals of LURN are to work collaboratively to 1) identify and explain the important subtypes of lower urinary tract symptoms; 2) improve the measurement of patient experiences of lower urinary tract symptoms; 3) disseminate novel findings to researchers, clinicians and patients; and 4) generate data, research tools and biological samples for future studies. Materials and Methods As a first step in understanding subtypes of lower urinary tract symptoms, LURN will focus on disorders of urinary sensation (eg urgency) and their causes. These are being examined with respect to patient experience, organism or systemic factors, genitourinary organs and tissues, and cellular/molecular factors. This is being achieved via an observational cohort study that is currently enrolling patients with lower urinary tract symptoms (target number 1,000) and that will extensively characterize patients with lower urinary tract symptoms. Future studies embedded within the observational cohort study will focus on neuroimaging and sensory testing, biomarkers and organ based factors. To advance the science of measurement of lower urinary tract symptoms, LURN is also developing and evaluating a comprehensive set of self-report questions to provide more granular assessments of lower urinary tract symptoms. Results LURN has taken its first steps by developing a framework for studying lower urinary tract symptom subtypes. Conclusions In developing this framework, LURN is choosing an initial domain on which to focus (sensory experiences), and creating and executing protocols designed to improve measurement of self-reported symptoms and identify patient subtypes.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalJournal of Urology
Volume196
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Lower Urinary Tract Symptoms
Urinary Tract
Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Sensation Disorders
Neuroimaging
Self Report
Observational Studies
Cohort Studies
Biomarkers
Research Personnel

Keywords

  • government agencies
  • lower urinary tract symptoms
  • research

ASJC Scopus subject areas

  • Urology

Cite this

Yang, C. C., Weinfurt, K. P., Merion, R. M., Kirkali, Z., Amundsen, C., Weinfurt, K., ... LURN Study Group (2016). Symptoms of Lower Urinary Tract Dysfunction Research Network. Journal of Urology, 196(1), 146-152. https://doi.org/10.1016/j.juro.2016.01.007
Yang, Claire C. ; Weinfurt, Kevin P. ; Merion, Robert M. ; Kirkali, Ziya ; Amundsen, Cindy ; Weinfurt, Kevin ; Flynn, Kathryn ; Fraser, Matthew O. ; Harshbarger, Todd ; Peterson, Drew ; Preud'homme, Xavier A. ; Siddiqui, Nazema ; Webster, George ; Dombeck, Carrie ; Gilliam, Robin ; Hayes, Akira ; Longoria, Nicole ; McLean, Shantae ; Kreder, Karl ; Bradley, Catherine S. ; Erickson, Bradley A. ; Lutgendorf, Susan K. ; Magnotta, Vince ; O'Donnell, Michael A. ; Sung, Vivian ; Moss, Linda ; Lopez, Andrea ; Cella, David ; Helfand, Brian T. ; Griffith, James ; Hairston, John C. ; Kenton, Kimberly ; Parrish, Todd ; Chan, Jennie Yu Fan ; Alverdy, Alexandria ; Buono, Sarah ; Corona, Maria ; Nero, Jasmine ; Talaty, Pooja ; Venezuela, Veronica ; Clemens, J. Quentin ; Berger, Mitch ; DeLancey, John ; Fenner, Dee ; Harris, Rick ; Harte, Steve ; Pelletier-Cameron, Anne ; Wei, John ; Drnek, Linda ; Dutta, Nina ; LURN Study Group ; LURN Study Group. / Symptoms of Lower Urinary Tract Dysfunction Research Network. In: Journal of Urology. 2016 ; Vol. 196, No. 1. pp. 146-152.
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abstract = "Purpose To address gaps in understanding and treating lower urinary tract symptoms, the NIDDK created the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The goals of LURN are to work collaboratively to 1) identify and explain the important subtypes of lower urinary tract symptoms; 2) improve the measurement of patient experiences of lower urinary tract symptoms; 3) disseminate novel findings to researchers, clinicians and patients; and 4) generate data, research tools and biological samples for future studies. Materials and Methods As a first step in understanding subtypes of lower urinary tract symptoms, LURN will focus on disorders of urinary sensation (eg urgency) and their causes. These are being examined with respect to patient experience, organism or systemic factors, genitourinary organs and tissues, and cellular/molecular factors. This is being achieved via an observational cohort study that is currently enrolling patients with lower urinary tract symptoms (target number 1,000) and that will extensively characterize patients with lower urinary tract symptoms. Future studies embedded within the observational cohort study will focus on neuroimaging and sensory testing, biomarkers and organ based factors. To advance the science of measurement of lower urinary tract symptoms, LURN is also developing and evaluating a comprehensive set of self-report questions to provide more granular assessments of lower urinary tract symptoms. Results LURN has taken its first steps by developing a framework for studying lower urinary tract symptom subtypes. Conclusions In developing this framework, LURN is choosing an initial domain on which to focus (sensory experiences), and creating and executing protocols designed to improve measurement of self-reported symptoms and identify patient subtypes.",
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author = "Yang, {Claire C.} and Weinfurt, {Kevin P.} and Merion, {Robert M.} and Ziya Kirkali and Cindy Amundsen and Kevin Weinfurt and Kathryn Flynn and Fraser, {Matthew O.} and Todd Harshbarger and Drew Peterson and Preud'homme, {Xavier A.} and Nazema Siddiqui and George Webster and Carrie Dombeck and Robin Gilliam and Akira Hayes and Nicole Longoria and Shantae McLean and Karl Kreder and Bradley, {Catherine S.} and Erickson, {Bradley A.} and Lutgendorf, {Susan K.} and Vince Magnotta and O'Donnell, {Michael A.} and Vivian Sung and Linda Moss and Andrea Lopez and David Cella and Helfand, {Brian T.} and James Griffith and Hairston, {John C.} and Kimberly Kenton and Todd Parrish and Chan, {Jennie Yu Fan} and Alexandria Alverdy and Sarah Buono and Maria Corona and Jasmine Nero and Pooja Talaty and Veronica Venezuela and Clemens, {J. Quentin} and Mitch Berger and John DeLancey and Dee Fenner and Rick Harris and Steve Harte and Anne Pelletier-Cameron and John Wei and Linda Drnek and Nina Dutta and {LURN Study Group} and {LURN Study Group}",
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Yang, CC, Weinfurt, KP, Merion, RM, Kirkali, Z, Amundsen, C, Weinfurt, K, Flynn, K, Fraser, MO, Harshbarger, T, Peterson, D, Preud'homme, XA, Siddiqui, N, Webster, G, Dombeck, C, Gilliam, R, Hayes, A, Longoria, N, McLean, S, Kreder, K, Bradley, CS, Erickson, BA, Lutgendorf, SK, Magnotta, V, O'Donnell, MA, Sung, V, Moss, L, Lopez, A, Cella, D, Helfand, BT, Griffith, J, Hairston, JC, Kenton, K, Parrish, T, Chan, JYF, Alverdy, A, Buono, S, Corona, M, Nero, J, Talaty, P, Venezuela, V, Clemens, JQ, Berger, M, DeLancey, J, Fenner, D, Harris, R, Harte, S, Pelletier-Cameron, A, Wei, J, Drnek, L, Dutta, N, LURN Study Group & LURN Study Group 2016, 'Symptoms of Lower Urinary Tract Dysfunction Research Network', Journal of Urology, vol. 196, no. 1, pp. 146-152. https://doi.org/10.1016/j.juro.2016.01.007

Symptoms of Lower Urinary Tract Dysfunction Research Network. / Yang, Claire C.; Weinfurt, Kevin P.; Merion, Robert M.; Kirkali, Ziya; Amundsen, Cindy; Weinfurt, Kevin; Flynn, Kathryn; Fraser, Matthew O.; Harshbarger, Todd; Peterson, Drew; Preud'homme, Xavier A.; Siddiqui, Nazema; Webster, George; Dombeck, Carrie; Gilliam, Robin; Hayes, Akira; Longoria, Nicole; McLean, Shantae; Kreder, Karl; Bradley, Catherine S.; Erickson, Bradley A.; Lutgendorf, Susan K.; Magnotta, Vince; O'Donnell, Michael A.; Sung, Vivian; Moss, Linda; Lopez, Andrea; Cella, David; Helfand, Brian T.; Griffith, James; Hairston, John C.; Kenton, Kimberly; Parrish, Todd; Chan, Jennie Yu Fan; Alverdy, Alexandria; Buono, Sarah; Corona, Maria; Nero, Jasmine; Talaty, Pooja; Venezuela, Veronica; Clemens, J. Quentin; Berger, Mitch; DeLancey, John; Fenner, Dee; Harris, Rick; Harte, Steve; Pelletier-Cameron, Anne; Wei, John; Drnek, Linda; Dutta, Nina; LURN Study Group; LURN Study Group.

In: Journal of Urology, Vol. 196, No. 1, 01.07.2016, p. 146-152.

Research output: Contribution to journalArticle

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T1 - Symptoms of Lower Urinary Tract Dysfunction Research Network

AU - Yang, Claire C.

AU - Weinfurt, Kevin P.

AU - Merion, Robert M.

AU - Kirkali, Ziya

AU - Amundsen, Cindy

AU - Weinfurt, Kevin

AU - Flynn, Kathryn

AU - Fraser, Matthew O.

AU - Harshbarger, Todd

AU - Peterson, Drew

AU - Preud'homme, Xavier A.

AU - Siddiqui, Nazema

AU - Webster, George

AU - Dombeck, Carrie

AU - Gilliam, Robin

AU - Hayes, Akira

AU - Longoria, Nicole

AU - McLean, Shantae

AU - Kreder, Karl

AU - Bradley, Catherine S.

AU - Erickson, Bradley A.

AU - Lutgendorf, Susan K.

AU - Magnotta, Vince

AU - O'Donnell, Michael A.

AU - Sung, Vivian

AU - Moss, Linda

AU - Lopez, Andrea

AU - Cella, David

AU - Helfand, Brian T.

AU - Griffith, James

AU - Hairston, John C.

AU - Kenton, Kimberly

AU - Parrish, Todd

AU - Chan, Jennie Yu Fan

AU - Alverdy, Alexandria

AU - Buono, Sarah

AU - Corona, Maria

AU - Nero, Jasmine

AU - Talaty, Pooja

AU - Venezuela, Veronica

AU - Clemens, J. Quentin

AU - Berger, Mitch

AU - DeLancey, John

AU - Fenner, Dee

AU - Harris, Rick

AU - Harte, Steve

AU - Pelletier-Cameron, Anne

AU - Wei, John

AU - Drnek, Linda

AU - Dutta, Nina

AU - LURN Study Group

AU - LURN Study Group

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Purpose To address gaps in understanding and treating lower urinary tract symptoms, the NIDDK created the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The goals of LURN are to work collaboratively to 1) identify and explain the important subtypes of lower urinary tract symptoms; 2) improve the measurement of patient experiences of lower urinary tract symptoms; 3) disseminate novel findings to researchers, clinicians and patients; and 4) generate data, research tools and biological samples for future studies. Materials and Methods As a first step in understanding subtypes of lower urinary tract symptoms, LURN will focus on disorders of urinary sensation (eg urgency) and their causes. These are being examined with respect to patient experience, organism or systemic factors, genitourinary organs and tissues, and cellular/molecular factors. This is being achieved via an observational cohort study that is currently enrolling patients with lower urinary tract symptoms (target number 1,000) and that will extensively characterize patients with lower urinary tract symptoms. Future studies embedded within the observational cohort study will focus on neuroimaging and sensory testing, biomarkers and organ based factors. To advance the science of measurement of lower urinary tract symptoms, LURN is also developing and evaluating a comprehensive set of self-report questions to provide more granular assessments of lower urinary tract symptoms. Results LURN has taken its first steps by developing a framework for studying lower urinary tract symptom subtypes. Conclusions In developing this framework, LURN is choosing an initial domain on which to focus (sensory experiences), and creating and executing protocols designed to improve measurement of self-reported symptoms and identify patient subtypes.

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Yang CC, Weinfurt KP, Merion RM, Kirkali Z, Amundsen C, Weinfurt K et al. Symptoms of Lower Urinary Tract Dysfunction Research Network. Journal of Urology. 2016 Jul 1;196(1):146-152. https://doi.org/10.1016/j.juro.2016.01.007